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Blood, Vol. 92 No. 8 (October 15), 1998:
pp. 2934-2939
Serum Transferrin Receptor and Transferrin Receptor-Ferritin Index
Identify Healthy Subjects With Subclinical Iron Deficits
Pauli Suominen,
Kari Punnonen,
Allan Rajamäki, and
Kerttu Irjala
From the Central Laboratory, Department of Clinical Chemistry and
Department of Hematology, Turku University Central Hospital, Turku,
Finland.
Despite the established utility of serum transferrin receptor
(sTfR), serum ferritin, and the sTfR/log ferritin ratio (TfR-F Index)
in the diagnosis of iron deficiency (ID) anemia, the numeric values of
these parameters, which are indicative of subclinical ID, remain to be
clearly defined. In this study, 65 apparently healthy nonanemic adults
(22 men and 43 women) were treated with 3 months of oral iron
supplementation to evaluate its effect on parameters reflecting iron
status and to determine the prevalence of subclinical iron deficiency
in apparently healthy adults. Significant supplementation-induced
changes were observed in sTfR, ferritin, and TfR-F Index values in
women, whereas in men, none of the studied parameters showed any
significant change. Iron-deficient erythropoiesis (IDE) was not
observed in men, but was found in 17 women (40%). Although individuals
with a compromised iron status may be represented in substantial
numbers in conventional reference populations, they can be readily
identified using sTfR, ferritin, and TfR-F Index determinations.
© 1998 by The American Society of Hematology.
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