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Blood, Vol. 92 No. 9 (November 1), 1998:
pp. 3050-3056
RAPID COMMUNICATION
Abnormal Microsomal Detoxification Implicated in Fanconi Anemia Group
C by Interaction of the FAC Protein With NADPH Cytochrome P450
Reductase
Frank A.E. Kruyt,
Taizo Hoshino,
Johnson M. Liu,
Pius Joseph,
Anil
K. Jaiswal, and
Hagop Youssoufian
From the Departments of Molecular and Human Genetics, Pharmacology
and Medicine, Baylor College of Medicine, Houston, TX 77030; and the
Hematology Branch, National Heart, Lung and Blood Institute, Bethesda,
MD.
The FAC protein encoded by the Fanconi anemia (FA) complementation
group C gene is thought to function in the cytoplasm at a step before
DNA repair. Because FA cells are susceptible to mitomycin C, we
considered the possibility that FAC might interact with enzymes
involved in the bioreductive activation of this drug. Here we report
that FAC binds to NADPH cytochrome-P450 reductase (RED), a microsomal
membrane protein involved in electron transfer, in both transfected
COS-1 and normal murine liver cells. FAC-RED interaction requires the
amino-terminal region of FAC and the cytosolic, membrane-proximal
domain of the reductase. The latter contains a known binding site for
flavin mononucleotide (FMN). Addition of FMN to cytosolic lysates
disrupts FAC-reductase complexes, while flavin dinucleotide, which
binds to a distinct carboxy-terminal domain, fails to
alter FAC-RED complexes at concentrations similar to FMN. FAC is also
functionally coupled to this enzyme as its expression in COS-1 cells
suppresses the ability of RED to reduce cytochrome c in the presence of
NADPH. We propose that FAC plays a fundamental role in vivo by
attenuating the activity of RED, thereby regulating a major
detoxification pathway in mammalian cells.
© 1998 by The American Society of Hematology.
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106(1):
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|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
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|
|
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|
|
|
|
|
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279(6):
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|
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|
|
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|
|
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|
|
|
|
|
|
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|
|
|
|
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|
|
|
|
|
|
|
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[PDF]
|
|
|
|
|
|
|
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95(12):
3970 - 3977.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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21(5):
1067 - 1068.
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[Full Text]
[PDF]
|
|
|
|
|
|
|
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21(2):
213 - 220.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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94(11):
3737 - 3747.
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[Full Text]
[PDF]
|
|
|
|
|
|
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34212 - 34218.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Waisfisz, J. P. de Winter, F. A. E. Kruyt, J. de Groot, L. van der Weel, L. M. Dijkmans, Y. Zhi, F. Arwert, R. J. Scheper, H. Youssoufian, et al.
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96(18):
10320 - 10325.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
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R. Abu-Issa, G. Eichele, and H. Youssoufian
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94(2):
818 - 824.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
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I. Garcia-Higuera, Y. Kuang, D. Naf, J. Wasik, and A. D. D'Andrea
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19(7):
4866 - 4873.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. S. Haneline, T. A. Gobbett, R. Ramani, M. Carreau, M. Buchwald, M. C. Yoder, and D. W. Clapp
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July 1, 1999;
94(1):
1 - 8.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
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I. Garcia-Higuera, A. D. D'Andrea;, F. A.E. Kruyt, and H. Youssoufian
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Blood,
February 15, 1999;
93(4):
1430 - 1432.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Youssoufian, F. A.E. Kruyt, and X. Li
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Blood,
January 1, 1999;
93(1):
363 - 369.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Qiao, A. Moss, and G. M. Kupfer
Fanconi Anemia Proteins Localize to Chromatin and the Nuclear Matrix in a DNA Damage- and Cell Cycle-regulated Manner
J. Biol. Chem.,
June 22, 2001;
276(26):
23391 - 23396.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
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