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Blood, Vol. 92 No. 9 (November 1), 1998:
pp. 3338-3345
OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at
Priming and Promotes the Differentiation of Naive Human
CD4+ T Cells Into High IL-4-Producing Effectors
Yusei Ohshima,
Liang-Peng Yang,
Takashi Uchiyama,
Yuetsu Tanaka,
Peter Baum,
Martin Sergerie,
Patrice Hermann, and
Guy Delespesse
From the University of Montreal, Centre de Recherche Louis-Charles
Simard, Notre-Dame Hospital, and the Department of Obstetrics and
Gynecology, Montreal, Quebec, Canada; the Institute for Virus Research,
Kyoto University, Kyoto, Japan; Kitasato University, Kitasato,
Sagamihara, Kanagawa, Japan; and Immunex Research and Development Corp,
Seattle, WA.
Th2 cell development is critically dependent on the presence of
interleukin-4 (IL-4) at priming. The cellular origin and the mechanisms
regulating this early production of IL-4 at the site of naive T-cell
priming are extensively investigated. We previously reported that
anti-CD3-activated and CD28-costimulated naive human CD4+ T cells themselves release very low but sufficient
levels of IL-4 to support their development into high IL-4-producing
cells. We show here that ligation of OX40 Ag, a member of the tumor
necrosis factor receptor (TNF-R) family, on activated
umbilical cord blood CD4+ T cells upregulates IL-4
production at priming and thereby promotes their development into
effector cells producing high levels of the type 2 cytokines IL-4,
IL-5, and IL-13. OX40 ligation increases four times the expression of
IL-4 mRNA after 48 hours of anti-CD3/B7.1 activation and significantly
augments the release of IL-4 and IL-13 in primary cultures. The effects
of OX40 costimulation on Th cell differentiation are observed in the
presence of optimal and suboptimal CD28 stimulation. Because OX40
ligand is expressed on dendritic cells, the OX40 costimulation pathway
may be involved in the physiological regulation of Th cell development
by augmenting the differentiation of IL-4-producing cells.
© 1998 by The American Society of Hematology.
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|
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|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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167(1):
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|
|
|
|
|
|
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166(3):
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|
|
|
|
|
|
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165(8):
4624 - 4631.
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[Full Text]
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|
|
|
|
|
|
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J. Kjærgaard, J. Tanaka, J. A. Kim, K. Rothchild, A. Weinberg, and S. Shu
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|
|
|
|
|
|
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I. Gramaglia, A. Jember, S. D. Pippig, A. D. Weinberg, N. Killeen, and M. Croft
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165(6):
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Oh and M. C. Eichelberger
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74(17):
7738 - 7744.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
H. Tanaka, C. E. Demeure, M. Rubio, G. Delespesse, and M. Sarfati
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192(3):
405 - 412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. ATEN, A. ROOS, N. CLAESSEN, E. J. M. SCHILDER-TOL, I. J. M. TEN BERGE, and J. J. WEENING
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11(8):
1426 - 1438.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Morimoto, Y. Kanno, Y. Tanaka, Y. Tokano, H. Hashimoto, S. Jacquot, C. Morimoto, S. F. Schlossman, H. Yagita, K. Okumura, et al.
CD134L Engagement Enhances Human B Cell Ig Production: CD154/CD40, CD70/CD27, and CD134/CD134L Interactions Coordinately Regulate T Cell-Dependent B Cell Responses
J. Immunol.,
April 15, 2000;
164(8):
4097 - 4104.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. R. Rogers and M. Croft
CD28, Ox-40, LFA-1, and CD4 Modulation of Th1/Th2 Differentiation Is Directly Dependent on the Dose of Antigen
J. Immunol.,
March 15, 2000;
164(6):
2955 - 2963.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. D. Weinberg, M.-M. Rivera, R. Prell, A. Morris, T. Ramstad, J. T. Vetto, W. J. Urba, G. Alvord, C. Bunce, and J. Shields
Engagement of the OX-40 Receptor In Vivo Enhances Antitumor Immunity
J. Immunol.,
February 15, 2000;
164(4):
2160 - 2169.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Akiba, Y. Miyahira, M. Atsuta, K. Takeda, C. Nohara, T. Futagawa, H. Matsuda, T. Aoki, H. Yagita, and K. Okumura
Critical Contribution of Ox40 Ligand to T Helper Cell Type 2 Differentiation in Experimental Leishmaniasis
J. Exp. Med.,
January 17, 2000;
191(2):
375 - 380.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Murata, N. Ishii, H. Takano, S. Miura, L. C. Ndhlovu, M. Nose, T. Noda, and K. Sugamura
Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand
J. Exp. Med.,
January 17, 2000;
191(2):
365 - 374.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Lane
Role of Ox40 Signals in Coordinating Cd4 T Cell Selection, Migration, and Cytokine Differentiation in T Helper (Th)1 and Th2 Cells
J. Exp. Med.,
January 17, 2000;
191(2):
201 - 206.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. D. Pippig, C. Pena-Rossi, J. Long, W. R. Godfrey, D. J. Fowell, S. L. Reiner, M. L. Birkeland, R. M. Locksley, A. N. Barclay, and N. Killeen
Robust B Cell Immunity but Impaired T Cell Proliferation in the Absence of CD134 (OX40)
J. Immunol.,
December 15, 1999;
163(12):
6520 - 6529.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. S.K. Walker, A. Gulbranson-Judge, S. Flynn, T. Brocker, C. Raykundalia, M. Goodall, R. Forster, M. Lipp, and P. Lane
Compromised Ox40 Function in Cd28-Deficient Mice Is Linked with Failure to Develop Cxc Chemokine Receptor 5-Positive Cd4 Cells and Germinal Centers
J. Exp. Med.,
October 18, 1999;
190(8):
1115 - 1122.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Akiba, H. Oshima, K. Takeda, M. Atsuta, H. Nakano, A. Nakajima, C. Nohara, H. Yagita, and K. Okumura
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J. Immunol.,
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162(12):
7058 - 7066.
[Abstract]
[Full Text]
[PDF]
|
|
|
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|
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D. Jones, C. D.M. Fletcher, K. Pulford, A. Shahsafaei, and D. M. Dorfman
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93(10):
3487 - 3493.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Ohshima, L-P. Yang, M-N. Avice, M. Kurimoto, T. Nakajima, M. Sergerie, C. E. Demeure, M. Sarfati, and G. Delespesse
Naive Human CD4+ T Cells Are a Major Source of Lymphotoxin {alpha}
J. Immunol.,
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162(7):
3790 - 3794.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
