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Blood, Vol. 93 No. 1 (January 1), 1999:
pp. 260-267
Constitutive and Interleukin-7/Interleukin-15 Stimulated DNA Binding
of Myc, Jun, and Novel Myc-Like Proteins in Cutaneous T-Cell Lymphoma
Cells
J-Z. Qin,
R. Dummer,
G. Burg, and
U. Döbbeling
From the Department of Dermatology, University Hospital Zurich,
Zurich, Switzerland.
Members of the Myc and Jun/Fos gene families have been
found to be expressed in late stages of cutaneous T-cell lymphoma
(CTCL) and may be responsible for the transition from low-grade to
high-grade tumors. The composition of these complexes is an important
parameter, as the different homo- and heterodimeric jun and myc
complexes can have gene transcription activating or suppressing
activities. We determined the composition of the jun and myc
DNA-binding complexes in three CTCL cell lines and malignant cells of
seven Sézary patients by electrophoretic mobility shift assays
(EMSAs) and "supershift" assays in which specific antibodies
against the different members of the tested gene families were included
in the binding reactions. Complexes containing JunD were found in three
cell lines and two patients. The three cell lines and one patient
contained also c-Myc/Max heterodimers. Because c-Myc/Max heterodimers
are strong gene transcription activators and are necessary for
cell-cycle progression, they may play a role in the progression of
CTCL. JunD may also promote cell-cycle progression and influence the expression of cell death survival genes. Interleukin-7 (IL-7) and
IL-15, which have been identified as growth factors for CTCL cells,
stimulated the DNA binding of JunD and two novel c-Myc recognition site
(E-box) binding proteins, but not the DNA binding of c-Myc/Max
heterodimers.
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