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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Stroka, D. M. Articles by Ferran, C. Search for Related Content PubMed PubMed Citation Articles by Stroka, D. M. Articles by Ferran, C. Related Collections Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, Vol. 93 No. 11 (June 1), 1999: pp. 3803-3810 Overexpression of A1, an NF-B-Inducible Anti-Apoptotic Bcl Gene, Inhibits Endothelial Cell Activation Deborah M. Stroka, Anne Z. Badrichani, Fritz H. Bach, and Christiane Ferran From the Immunobiology Research Center, Beth Israel-Deaconess Medical Center, Harvard Medical School, Boston, MA. A1 is an anti-apoptotic bcl gene that is expressed in endothelial cells (EC) in response to pro-inflammatory stimuli. We show that in addition to protecting EC from apoptosis, A1 inhibits EC activation and its associated expression of pro-inflammatory proteins by inhibiting the transcription factor nuclear factor (NF)-B. This new anti-inflammatory function gives a broader dimension to the protective role of A1 in EC. We also show that activation of NF-B is essential for the expression of A1. Taken together, our data suggest that A1 downregulates not only the pro-apoptotic and pro-inflammatory response, but also its own expression, thus restoring a quiescent phenotype to EC. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: V. I. Patel, S. Daniel, C. R. Longo, G. V. Shrikhande, S. T. Scali, E. Czismadia, C. M. Groft, T. Shukri, C. Motley-Dore, H. E. Ramsey, et al. A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia FASEB J, July 1, 2006; 20(9): 1418 - 1430. [Abstract] [Full Text] [PDF] J. C. Reed, K. S. Doctor, and A. Godzik The Domains of Apoptosis: A Genomics Perspective Sci. Signal., June 29, 2004; 2004(239): re9 - re9. [Abstract] [Full Text] [PDF] A. Iwata, V. M. Stevenson, A. Minard, M. Tasch, J. Tupper, E. Lagasse, I. Weissman, J. M. Harlan, and R. K. Winn Over-Expression of Bcl-2 Provides Protection in Septic Mice by a trans Effect J. Immunol., September 15, 2003; 171(6): 3136 - 3141. [Abstract] [Full Text] [PDF] S. Brouard, P. O. Berberat, E. Tobiasch, M. P. Seldon, F. H. Bach, and M. P. 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