|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 93 No. 12 (June 15), 1999:
pp. 4418-4424
Normal Human Serum Contains Natural Antibodies Reactive With Autologous
ABO Blood Group Antigens
Sergio H. Spalter,
Srini V. Kaveri,
Emmanuelle Bonnin,
Jean-Claude Mani,
Jean-Pierre Cartron, and
Michel D. Kazatchkine
From INSERM U430 and Université Pierre et Marie Curie, Hopital
Broussais, Paris, France; CNRS UMR 9921, Montpellier, France; and
INSERM U76 and Institut National de Transfusion Sanguine, Paris,
France.
It is widely accepted that the serum of healthy individuals contains
natural antibodies only against those blood group A or B antigens that
are not expressed on the individual's red blood cells. The mechanisms
involved in tolerance to autologous blood group antigens remain
unclear. In the present study, we show that IgM and IgG antibodies
reactive with autologous blood group antigens are present in the
immunoglobulin fraction of normal human serum. Natural IgG anti-A
antibodies purified by affinity chromatography from IgG of individuals
of blood group A exhibited an affinity for A trisaccharide antigen in
the micromolar range and agglutinated A red cells at sixfold higher
concentrations than those required for agglutination with
affinity-purified anti-A IgG of individuals of blood group B. Whereas
autoantibodies reactive with self A and B antigens are readily detected
in purified IgG and IgM fractions, their expression is restricted in
whole serum as a result of complementary interactions between variable
regions of antibodies. These observations suggest that tolerance to
autologous ABO blood group antigens is dependent on peripheral control
of antibody autoreactivity.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
H. K. Parmentier, G. De Vries Reilingh, and A. Lammers
Decreased Specific Antibody Responses to {alpha}-Gal-Conjugated Antigen in Animals with Preexisting High Levels of Natural Antibodies Binding {alpha}-Gal Residues
Poult. Sci.,
May 1, 2008;
87(5):
918 - 926.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. G. Solheim
Universal pathogen-reduced plasma in elective open-heart surgery and liver resection.
Clin. Med. Res.,
September 1, 2006;
4(3):
209 - 217.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Milland, D. Christiansen, B. D. Lazarus, S. G. Taylor, P. X. Xing, and M. S. Sandrin
The Molecular Basis for Gal{alpha}(1,3)Gal Expression in Animals with a Deletion of the {alpha}1,3Galactosyltransferase Gene
J. Immunol.,
February 15, 2006;
176(4):
2448 - 2454.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Moreau, S. Lacroix-Desmazes, N. Stieltjes, E. Saenko, S. V. Kaveri, R. D'Oiron, Y. Sultan, D. Scandella, and M. D. Kazatchkine
Antibodies to the FVIII light chain that neutralize FVIII procoagulant activity are present in plasma of nonresponder patients with severe hemophilia A and in normal polyclonal human IgG
Blood,
June 1, 2000;
95(11):
3435 - 3441.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Stahl, S. Lacroix-Desmazes, D. Heudes, L. Mouthon, S. V. Kaveri, and M. D. Kazatchkine
Altered control of self-reactive IgG by autologous IgM in patients with warm autoimmune hemolytic anemia
Blood,
January 1, 2000;
95(1):
328 - 335.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
