|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 93 No. 3 (February 1), 1999:
pp. 826-837
HCA, an Immunoglobulin-Like Adhesion Molecule Present on the
Earliest Human Hematopoietic Precursor Cells, Is Also Expressed by
Stromal Cells in Blood-Forming Tissues
Fernando Cortés,
Frédéric Deschaseaux,
Nobuko Uchida,
Marie-Claude Labastie,
Annabelle M. Friera,
Dongping He,
Pierre Charbord, and
Bruno Péault
From the Institut d'Embryologie Cellulaire et Moléculaire,
CNRS UPR 9064, Nogent-sur-Marne, France; the Établissement de
Transfusion Sanguine, Besançon, France; and SyStemix Inc, Palo
Alto, CA.
We have previously shown that the HCA/ALCAM (CD166) glycoprotein, a
member of the immunoglobulin family that mediates both homophilic and
heterophilic cell-cell adhesion, via the CD6 ligand, is expressed at
the surface of all of the most primitive CD38 /lo,
Thy-1+, rho123lo, CD34+
hematopoietic cells in human fetal liver and fetal and adult bone
marrow. In the present report we show that HCA is also expressed by
subsets of stromal cells in the primary hematopoietic sites that
sequentially develop in the human embryo and fetus, ie, the paraaortic
mesoderm, liver, thymus, and bone marrow. Adult bone marrow stromal
cells established in vitro, including those derived from
Stro-1+ progenitors and cells from immortalized cell
lines, express HCA. In contrast, no HCA expression could be detected in
peripheral lymphoid tissues, fetal spleen, and lymph nodes. HCA
membrane molecules purified from marrow stromal cells interact with
intact marrow stromal cells, CD34+ CD38
hematopoietic precursors, and CD3+ CD6+
peripheral blood lymphocytes. Finally, low but significant levels of
CD6 are here for the first time detected at the surface of CD34+ rho123med/lo progenitors in the bone
marrow and in mobilized blood from healthy individuals. Altogether,
these results indicate that the HCA/ALCAM surface molecule is involved
in homophilic or heterophilic (with CD6) adhesive interactions between
early hematopoietic progenitors and associated stromal cells in primary
blood-forming organs.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S.-C. Choi, K. D. Kim, J.-T. Kim, J. W. Kim, H. G. Lee, J.-M. Kim, Y.-S. Jang, D.-Y. Yoon, K. I. Kim, Y. Yang, et al.
Expression of human NDRG2 by myeloid dendritic cells inhibits down-regulation of activated leukocyte cell adhesion molecule (ALCAM) and contributes to maintenance of T cell stimulatory activity
J. Leukoc. Biol.,
January 1, 2008;
83(1):
89 - 98.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Ibanez, M.-R. Sarrias, M. Farnos, I. Gimferrer, C. Serra-Pages, J. Vives, and F. Lozano
Mitogen-Activated Protein Kinase Pathway Activation by the CD6 Lymphocyte Surface Receptor
J. Immunol.,
July 15, 2006;
177(2):
1152 - 1159.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Skottman, A.-M. Stromberg, E. Matilainen, J. Inzunza, O. Hovatta, and R. Lahesmaa
Unique Gene Expression Signature by Human Embryonic Stem Cells Cultured Under Serum-Free Conditions Correlates with Their Enhanced and Prolonged Growth in an Undifferentiated Stage
Stem Cells,
January 1, 2006;
24(1):
151 - 167.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Decraene, R. Benchaouir, M.-A. Dillies, D. Israeli, S. Bortoli, C. Rochon, P. Rameau, A. Pitaval, D. T.-L. Roux, O. Danos, et al.
Global transcriptional characterization of SP and MP cells from the myogenic C2C12 cell line: effect of FGF6
Physiol Genomics,
October 17, 2005;
23(2):
132 - 149.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Avril-Delplanque, I. Casal, N. Castillon, J. Hinnrasky, E. Puchelle, and B. Peault
Aquaporin-3 Expression in Human Fetal Airway Epithelial Progenitor Cells
Stem Cells,
August 1, 2005;
23(7):
992 - 1001.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Piazza, E. Cha, I. Bongarzone, S. Canevari, A. Bolognesi, L. Polito, A. Bargellesi, F. Sassi, S. Ferrini, and M. Fabbi
Internalization and recycling of ALCAM/CD166 detected by a fully human single-chain recombinant antibody
J. Cell Sci.,
April 1, 2005;
118(7):
1515 - 1525.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Gimferrer, M. Calvo, M. Mittelbrunn, M. Farnos, M. R. Sarrias, C. Enrich, J. Vives, F. Sanchez-Madrid, and F. Lozano
Relevance of CD6-Mediated Interactions in T Cell Activation and Proliferation
J. Immunol.,
August 15, 2004;
173(4):
2262 - 2270.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. W. Zimmerman, J. M. D. T. Nelissen, S. E. van Emst-de Vries, P. H. G. M. Willems, F. de Lange, J. G. Collard, F. N. van Leeuwen, and C. G. Figdor
Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKC{alpha} independently of Rho-like GTPases
J. Cell Sci.,
June 1, 2004;
117(13):
2841 - 2852.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Fujiwara, K. Tatsumi, K. Kosaka, Y. Sato, T. Higuchi, S. Yoshioka, M. Maeda, M. Ueda, and S. Fujii
Human Blastocysts and Endometrial Epithelial Cells Express Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166)
J. Clin. Endocrinol. Metab.,
July 1, 2003;
88(7):
3437 - 3443.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Chagraoui, A. Lepage-Noll, A. Anjo, G. Uzan, and P. Charbord
Fetal liver stroma consists of cells in epithelial-to-mesenchymal transition
Blood,
April 15, 2003;
101(8):
2973 - 2982.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Arai, O. Ohneda, T. Miyamoto, X. Q. Zhang, and T. Suda
Mesenchymal Stem Cells in Perichondrium Express Activated Leukocyte Cell Adhesion Molecule and Participate in Bone Marrow Formation
J. Exp. Med.,
June 17, 2002;
195(12):
1549 - 1563.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Ohneda, K. Ohneda, F. Arai, J. Lee, T. Miyamoto, Y. Fukushima, D. Dowbenko, L. A. Lasky, and T. Suda
ALCAM (CD166): its role in hematopoietic and endothelial development
Blood,
October 1, 2001;
98(7):
2134 - 2142.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. J. Rogers, B. S. Hall, J. Obiero, G. A. T. Targett, and C. J. Sutherland
A Model for Sequestration of the Transmission Stages of Plasmodium falciparum: Adhesion of Gametocyte-Infected Erythrocytes to Human Bone Marrow Cells
Infect. Immun.,
June 1, 2000;
68(6):
3455 - 3462.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. D. T. Nelissen, I. M. Peters, B. G. de Grooth, Y. van Kooyk, and C. G. Figdor
Dynamic Regulation of Activated Leukocyte Cell Adhesion Molecule-mediated Homotypic Cell Adhesion through the Actin Cytoskeleton
Mol. Biol. Cell,
June 1, 2000;
11(6):
2057 - 2068.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. M. Watt, L. H. Butler, M. Tavian, H.-J. Buhring, I. Rappold, P. J. Simmons, A. C. W. Zannettino, D. Buck, A. Fuchs, R. Doyonnas, et al.
Functionally defined CD164 epitopes are expressed on CD34+ cells throughout ontogeny but display distinct distribution patterns in adult hematopoietic and nonhematopoietic tissues
Blood,
May 15, 2000;
95(10):
3113 - 3124.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. C. L. T. van Kempen, J. M. D. T. Nelissen, W. G. J. Degen, R. Torensma, U. H. Weidle, H. P. J. Bloemers, C. G. Figdor, and G. W. M. Swart
Molecular Basis for the Homophilic Activated Leukocyte Cell Adhesion Molecule (ALCAM)-ALCAM Interaction
J. Biol. Chem.,
July 6, 2001;
276(28):
25783 - 25790.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
