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Blood, Vol. 93 No. 4 (February 15), 1999:
pp. 1164-1167
Bone Marrow Transplantation in Adult Thalassemic Patients
G. Lucarelli,
R.A. Clift,
M. Galimberti,
E. Angelucci,
C. Giardini,
D. Baronciani,
P. Polchi,
M. Andreani,
D. Gaziev,
B. Erer,
A. Ciaroni,
F. D'Adamo,
F. Albertini, and
P. Muretto
From the Divisione Ematologica e Centro Trapianto Midollo Osseo di
Muraglia and Servizio Anatomia Patologica, Azienda Ospedale S. Salvatore di Pesaro, Pesaro, Italy; and The Fred Hutchinson Cancer
Research Center, Seattle, WA.
One hundred seven adult patients with thalassemia aged from 17 through 35 years and transplanted from HLA-identical siblings between
November 1988 and September 1996 were evaluated on December 31, 1997. The outcome experience of 20 consecutive patients transplanted between
November 13, 1988 and January 10, 1991 and reported in September 1992 is updated after 5 additional years. The experience on 87 patients
transplanted between May 1991 and September 1996 is described and
evaluated as of the end of December 1997. Of 107 patients, 69 survive
between 1.5 and 9 years after transplantation. Sixty-six of these
patients do not have thalassemia and are identified as ex-thalassemic
after bone marrow transplantation. The youngest survivor is 20 years
old, 6 are older than 30 years, and the oldest is 37 years of age.
Patients with chronic active hepatitis at the time of transplant were
significantly more likely to die than patients without (P = .05; relative risk, 2.05). Marrow transplantation is a valid treatment
option for older patients with thalassemia who have suitable donors and
show deterioration with conventional therapy.
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