Blood, Vol. 93 No. 6 (March 15), 1999:
pp. 2038-2042
Spectral Karyotype Analysis of T-Cell Acute Leukemia
Janet D. Rowley,
Shalini Reshmi,
Katrin Carlson, and
Diane Roulston
From the Section of Hematology/Oncology, Department of Medicine,
University of Chicago, Chicago, IL.
Analysis of 15 cases of T-cell acute lymphoblastic leukemia with
spectral karyotyping (SKY), which can identify all chromosomes simultaneously, clarified the chromosome rearrangements in 3 cases and
confirmed them in 11 others; no abnormal cells were identified in 1 case, which had only 10% abnormal cells. Five of the latter cases had
a normal karyotype. Thus, the use of SKY substantially improves the
precision of karyotype analysis of malignant cells, which in turn leads
to a more accurate assessment of the genotypic abnormalities in those cells.
