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Blood, Vol. 93 No. 6 (March 15), 1999:
pp. 2067-2074
Cyclin A1 Expression in Leukemia and Normal Hematopoietic Cells
Rong Yang,
Tsuyoshi Nakamaki,
Michael Lübbert,
Jonathan Said,
Akiko Sakashita,
Bettina S. Freyaldenhoven,
Susan Spira,
Vong Huynh,
Carsten Müller, and
H. Phillip Koeffler
From the Division of Hematology/Oncology, Cedars-Sinai Research
Institute, UCLA School of Medicine, Los Angeles, CA; the Department of
Hematology, Showa University School of Medicine, Tokyo, Japan; the
Department of Hematology/Oncology, University of Freiburg Medical
Center, Freiburg, Germany; the Department of Pathology and Laboratory
Medicine, University of California, Los Angeles, Los Angeles, CA; the
Saitama Cancer Center, Saitama, Japan; and the Department of Pathology
and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Human cyclin A1 is a newly cloned, tissue-specific cyclin that is
prominently expressed in normal testis. In this study, we showed that
cyclin A1 was highly expressed in a subset of leukemia samples from
patients. The highest frequency of cyclin A1 overexpression was
observed in acute myelocytic leukemias, especially those that were at
the promyelocyte (M3) and myeloblast (M2) stages of development. Cyclin
A1 expression was also detected in normal CD34+
progenitor cells. The expression of cyclin A1 increased when these
cells were stimulated to undergo myeloid differentiation in vitro.
Taken together, our observations suggest that cyclin A1 may have a role
in hematopoiesis. High levels of cyclin A1 expression are especially
associated with certain leukemias blocked at the myeloblast and
promyelocyte stages of differentiation.
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