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Related Collections Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, Vol. 93 No. 8 (April 15), 1999: pp. 2543-2551 Functional Expression of the High Affinity Receptor for IgE (FcRI) in Human Platelets and Its' Intracellular Expression in Human Megakaryocytes Shunji Hasegawa, Ruby Pawankar, Katsuhiro Suzuki, Tatsutoshi Nakahata, Susumu Furukawa, Ko Okumura, and Chisei Ra From the Department of Immunology, Juntendo University, School of Medicine, Tokyo, Japan; Department of Pediatrics, Yamaguchi University, School of Medicine, Yamaguchi, Japan; and the Department of Clinical Oncology, The Institute of Medical Science, University of Tokyo, Tokyo, Japan. The high affinity IgE receptor (FcRI) expressed on the cell surface of mast cells and basophils is the key molecule in triggering the IgE-mediated allergic reaction. Recently, it was elucidated that the FcRI is expressed on a variety of other cells like Langerhans cells, monocytes, and eosinophils, and the functional importance of the FcRI expression in Langerhans cells was also shown. Some studies suggest that human platelets may play important roles in allergic inflammation through the cell-surface expression of the FcRII and FcRII. Here, we report that human platelets and megakaryocytes constitutively express the messenger RNA and protein for the FcRI. Although the FcRI is expressed on the cell surface of human platelets, it is only detected in the cytoplasm of human megakaryocytes. We also confirmed that human platelets express the genes for the , , and  chains of the FcRI without any defined mutations. Furthermore, stimulation of human platelets via the FcRI induced the release of serotonin and RANTES (Regulated on Activation, Normal T Expressed, and presumably Secreted). Taken together, these results suggest a novel and important role for human platelets in perpetuating allergic inflammation through the expression of and activation via the FcRI. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Qian, F. Xie, A. W. Gibson, J. C. Edberg, R. P. Kimberly, and J. Wu Functional expression of IgA receptor Fc{alpha}RI on human platelets J. Leukoc. Biol., December 1, 2008; 84(6): 1492 - 1500. [Abstract] [Full Text] [PDF] S. C. Pitchford, S. Momi, S. Baglioni, L. Casali, S. Giannini, R. Rossi, C. P. Page, and P. Gresele Allergen Induces the Migration of Platelets to Lung Tissue in Allergic Asthma Am. J. Respir. Crit. Care Med., March 15, 2008; 177(6): 604 - 612. [Abstract] [Full Text] [PDF] R. Tamagawa-Mineoka, N. Katoh, E. Ueda, H. Takenaka, M. Kita, and S. 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