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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ruggeri, Z. M. Articles by Saldívar, E. Search for Related Content PubMed PubMed Citation Articles by Ruggeri, Z. M. Articles by Saldívar, E. Related Collections Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, Vol. 94 No. 1 (July 1), 1999: pp. 172-178 Contribution of Distinct Adhesive Interactions to Platelet Aggregation in Flowing Blood Zaverio M. Ruggeri, Judith A. Dent, and Enrique Saldívar From the Roon Research Center for Arteriosclerosis and Thrombosis, the Division of Experimental Hemostasis and Thrombosis, the Department of Molecular and Experimental Medicine, and the Department of Vascular Biology, The Scripps Research Institute, La Jolla, CA. Aggregation of blood platelets contributes to the arrest of bleeding at sites of vascular injury, but it can occlude atherosclerotic arteries and precipitate diseases such as myocardial infarction. The bonds that link platelets under flow conditions were identified using confocal videomicroscopy in real time. Glycoprotein (GP) Ib and von Willebrand factor (vWF) acted in synergy with IIb3 and fibrinogen to sustain platelet accrual at the apex of thrombi where three-dimensional growth resulted in increasing shear rates. The specific function of distinct adhesion pathways in response to changing hemodynamic conditions helps to explain hemostatic and thrombotic processes. 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