|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 94 No. 10 (November 15), 1999:
pp. 3294-3306
Improved Treatment Results in Childhood B-Cell Neoplasms With Tailored
Intensification of Therapy: A Report of the
Berlin-Frankfurt-Münster Group Trial NHL-BFM 90
Alfred Reiter,
Martin Schrappe,
Markus Tiemann,
Wolf-Dieter Ludwig,
Elif Yakisan,
Martin Zimmermann,
Georg Mann,
Andreas Chott,
Wolfram Ebell,
Thomas Klingebiel,
Norbert Graf,
Bernhard Kremens,
Stefan Müller-Weihrich,
Hans-Jürgen Plüss,
Felix Zintl,
Günter Henze, and
Hansjörg Riehm
From the Department of Pediatric Hematology and Oncology,
Medizinische Hochschule, Hannover, Germany; the Lymphnode Registry of
The Society of German Pathologists, Institute of Hematopathology,
Christian-Albrechts-Universität, Kiel, Germany; the Department of
Hematology, Oncology and Tumor Immunology, Charité, Humboldt
University Berlin, Berlin, Germany; the St. Anna Kinderspital, Vienna,
Austria; the Department of Pathology, University of Vienna, Vienna,
Austria; the Department of Pediatric Hematology and Oncology,
Charité, Humboldt University, Berlin, Germany; the Department of
Pediatrics, University of Tübingen, Tübingen, Germany; the
Department of Pediatrics, University of Saarland, Homburg, Germany; the
Department of Pediatric Hematology and Oncology, University of Essen,
Essen, Germany; the Department of Pediatrics, Technical University,
München, Germany; the Department of Pediatrics, University of
Zürich, Zürich, Switzerland; and the Department of
Pediatrics, Friedrich Schiller University, Jena, Germany.
In study NHL-BFM 90, we investigated whether the serum lactate
dehydrogenase (LDH) concentration and early response are useful markers
for stratification of therapy for childhood B-cell neoplasms in
addition to stage, if the outcome of patients with abdominal stage III
and LDH  500 U/L can be improved by high-dose (HD) methotrexate (MTX)
at 5 g/m2 instead of intermediate-dose (ID) MTX at 500 mg/m2 in the preceding study 86; whether 2 therapy courses
are enough for patients with complete resection; and whether combined
systemic and intraventricular chemotherapy is efficacious for central
nervous system-positive (CNS+) patients.
After a cytoreductive prephase, treatment was stratified into 3 risk
groups: patients in R1 (completely resected) received 2 5-day courses
(ID-MTX, dexamethasone, oxazaphorins, etoposide, cytarabine,
doxorubicin, and intrathecal therapy), patients in R2 (extra-abdominal
primary only or abdominal tumor and LDH <500 U/L) received 4 courses
containing HD-MTX, and patients in R3 (abdominal primary and LDH 500
U/L or bone marrow/CNS/multilocal bone disease) received 6 courses.
Incomplete responders after 2 courses received an intensification
containing HD-cytarabine/etoposide. Patients with no or necrotic tumor
thereafter received 3 more courses; 6 patients with viable tumor
received autologous bone marrow transplantation. From April 1990 through March 1995, 413 evaluable patients were enrolled (R1, 17%; R2,
40%; and R3, 43%). The 6-year event-free survival (pEFS) was 89% ± 2% for all and 100%, 96% ±2%, and 78% ± 3% in R1,
R2, and R3, respectively. The pEFS of patients with abdominal stage III
and LDH 500 U/L was 81% ± 4% as compared with 43% ± 10% in
study 86. Of 26 CNS+ patients, 5 died early, but only 3 relapsed.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. JAGER, C. ZILKENS, B. WESTHOFF, E. M. JELINEK, G. KOZINA, and R. KRAUSPE
Efficiency of Iloprost Treatment for Chemotherapy-associated Osteonecrosis after Childhood Cancer
Anticancer Res,
August 1, 2009;
29(8):
3433 - 3440.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Shafer, H. Wu, T. Al-Saleem, K. Reddy, H. Borghaei, S. Lessin, and M. Smith
Cutaneous Precursor B-Cell Lymphoblastic Lymphoma in 2 Adult Patients: Clinicopathologic and Molecular Cytogenetic Studies With a Review of the Literature
Arch Dermatol,
September 1, 2008;
144(9):
1155 - 1162.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Klapper, M. Szczepanowski, B. Burkhardt, H. Berger, M. Rosolowski, S. Bentink, C. Schwaenen, S. Wessendorf, R. Spang, P. Moller, et al.
Molecular profiling of pediatric mature B-cell lymphoma treated in population-based prospective clinical trials
Blood,
August 15, 2008;
112(4):
1374 - 1381.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Schwartz, K. Borner, K. Muller, P. Martus, L. Fischer, A. Korfel, T. Auton, and E. Thiel
Glucarpidase (Carboxypeptidase G2) Intervention in Adult and Elderly Cancer Patients with Renal Dysfunction and Delayed Methotrexate Elimination After High-Dose Methotrexate Therapy
Oncologist,
November 1, 2007;
12(11):
1299 - 1308.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Cooney-Qualter, M. Krailo, A. Angiolillo, R. A. Fawwaz, G. Wiseman, L. Harrison, V. Kohl, P. C. Adamson, J. Ayello, C. vande Ven, et al.
A Phase I Study of 90Yttrium-Ibritumomab-Tiuxetan in Children and Adolescents with Relapsed/Refractory CD20-Positive Non Hodgkin's Lymphoma: A Children's Oncology Group Study
Clin. Cancer Res.,
September 15, 2007;
13(18):
5652s - 5660s.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Salzburg, B. Burkhardt, M. Zimmermann, O. Wachowski, W. Woessmann, I. Oschlies, W. Klapper, H.-H. Wacker, W.-D. Ludwig, F. Niggli, et al.
Prevalence, Clinical Pattern, and Outcome of CNS Involvement in Childhood and Adolescent Non-Hodgkin's Lymphoma Differ by Non-Hodgkin's Lymphoma Subtype: A Berlin-Frankfurt-Munster Group Report
J. Clin. Oncol.,
September 1, 2007;
25(25):
3915 - 3922.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Patte, A. Auperin, M. Gerrard, J. Michon, R. Pinkerton, R. Sposto, C. Weston, M. Raphael, S. L. Perkins, K. McCarthy, et al.
Results of the randomized international FAB/LMB96 trial for intermediate risk B-cell non-Hodgkin lymphoma in children and adolescents: it is possible to reduce treatment for the early responding patients
Blood,
April 1, 2007;
109(7):
2773 - 2780.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Cairo, M. Gerrard, R. Sposto, A. Auperin, C. R. Pinkerton, J. Michon, C. Weston, S. L. Perkins, M. Raphael, K. McCarthy, et al.
Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents
Blood,
April 1, 2007;
109(7):
2736 - 2743.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Reiter
Diagnosis and Treatment of Childhood Non-Hodgkin Lymphoma
Hematology,
January 1, 2007;
2007(1):
285 - 296.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. T. Sandlund
Should Adolescents with NHL Be Treated as Old Children or Young Adults?
Hematology,
January 1, 2007;
2007(1):
297 - 303.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. T. Wong
Management of Central Nervous System Lymphomas Using Monoclonal Antibodies: Challenges and Opportunities
Clin. Cancer Res.,
October 1, 2005;
11(19):
7151s - 7157s.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Laver, J. M. Kraveka, R. E. Hutchison, M. Chang, J. Kepner, M. Schwenn, N. Tarbell, S. Desai, S. Weitzman, H. J. Weinstein, et al.
Advanced-Stage Large-Cell Lymphoma in Children and Adolescents: Results of a Randomized Trial Incorporating Intermediate-Dose Methotrexate and High-Dose Cytarabine in the Maintenance Phase of the APO Regimen: A Pediatric Oncology Group Phase III Trial
J. Clin. Oncol.,
January 20, 2005;
23(3):
541 - 547.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Smeland, A. K. Blystad, S. O. Kvaloy, I. M. Ikonomou, J. Delabie, G. Kvalheim, J. Hammerstrom, G. F. Lauritzsen, and H. Holte
Treatment of Burkitt's/Burkitt-like lymphoma in adolescents and adults: a 20-year experience from the Norwegian Radium Hospital with the use of three successive regimens
Ann. Onc.,
July 1, 2004;
15(7):
1072 - 1078.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Pels, I. G.H. Schmidt-Wolf, A. Glasmacher, H. Schulz, A. Engert, V. Diehl, A. Zellner, G. Schackert, H. Reichmann, F. Kroschinsky, et al.
Primary Central Nervous System Lymphoma: Results of a Pilot and Phase II Study of Systemic and Intraventricular Chemotherapy With Deferred Radiotherapy
J. Clin. Oncol.,
December 15, 2003;
21(24):
4489 - 4495.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Karajannis, M. Hummel, I. Oschlies, I. Anagnostopoulos, M. Zimmermann, H. Stein, R. Parwaresch, and A. Reiter
Epstein-Barr virus infection in Western European pediatric non-Hodgkin lymphomas
Blood,
December 1, 2003;
102(12):
4244 - 4244.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Seidemann, M. Tiemann, I. Lauterbach, G. Mann, I. Simonitsch, K. Stankewitz, M. Schrappe, M. Zimmermann, C. Niemeyer, R. Parwaresch, et al.
Primary Mediastinal Large B-Cell Lymphoma With Sclerosis in Pediatric and Adolescent Patients: Treatment and Results From Three Therapeutic Studies of the Berlin-Frankfurt-Munster Group
J. Clin. Oncol.,
May 1, 2003;
21(9):
1782 - 1789.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Hollender, S. Kvaloy, O. Nome, E. Skovlund, K. Lote, and H. Holte
Central nervous system involvement following diagnosis of non-Hodgkin's lymphoma: a risk model
Ann. Onc.,
July 1, 2002;
13(7):
1099 - 1107.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Magrath
Molecular Characteristics of Diffuse Large-B-Cell Lymphoma
N. Engl. J. Med.,
June 20, 2002;
346(25):
1998 - 1999.
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Spreafico, M. Massimino, R. Luksch, M. Casanova, G. S. Cefalo, P. Collini, A. Ferrari, D. Polastri, M. Terenziani, M. Gasparini, et al.
Intensive, Very Short-Term Chemotherapy for Advanced Burkitt's Lymphoma in Children
J. Clin. Oncol.,
June 15, 2002;
20(12):
2783 - 2788.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Patte, A. Laplanche, A. I. Bertozzi, A. Baruchel, D. Frappaz, C. Schmitt, F. Mechinaud, B. Nelken, P. Boutard, and J. Michon
Granulocyte Colony-Stimulating Factor in Induction Treatment of Children With Non-Hodgkin's Lymphoma: A Randomized Study of the French Society of Pediatric Oncology
J. Clin. Oncol.,
January 15, 2002;
20(2):
441 - 448.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lister, L. E. Abrey, and J. T. Sandlund
Central Nervous System Lymphoma
Hematology,
January 1, 2002;
2002(1):
283 - 296.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C. Patte, A. Auperin, J. Michon, H. Behrendt, G. Leverger, D. Frappaz, P. Lutz, C. Coze, Y. Perel, M. Raphael, et al.
The Societe Francaise d'Oncologie Pediatrique LMB89 protocol: highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia
Blood,
June 1, 2001;
97(11):
3370 - 3379.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Lones, S. L. Perkins, R. Sposto, M. E. Kadin, C. R. Kjeldsberg, J. F. Wilson, and M. S. Cairo
Large-Cell Lymphoma Arising in the Mediastinum in Children and Adolescents Is Associated With an Excellent Outcome: A Children's Cancer Group Report
J. Clin. Oncol.,
November 15, 2000;
18(22):
3845 - 3853.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
