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Blood, Vol. 94 No. 10 (November 15), 1999: pp. 3365-3365

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  Early erythroblastic leukemia. This leukemic blast cell displays typical ultrastructure. The nucleus contains mainly euchromatin and prominent nucleolus structures. Characteristic granules called theta  granules (theta ) because they resemble the greek letter theta and ferritin containing granules (F) are present in the juxta-nuclear region near the centriole (c). Large size mitochondria (m) and lipid inclusions (L) are frequent (original magnification ×18,000). (Inset) High magnification of the characteristic granule ultrastructure. Ferritin molecules are identified in the granules by their density and shape (F). theta  granules exhibit complex internal structures (original magnification ×54,600). (Courtesy of Elisabeth M. Cramer, MD, PhD, INSERM U. 474, Hopital Henri Mondor, 51 av. du Marechal de Lattre-de-Tassigny, Creteil 94010, France.)


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