|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 94 No. 12 (December 15), 1999:
pp. 4210-4219
Interleukin-15 as an Activator of Natural Killer Cell-Mediated
Antiviral Response
Jean Gosselin,
Andru TomoÏu,
Robert C. Gallo, and
Louis Flamand
From the Laboratory of Viral Immunology, Laboratory of Virology,
Rheumatology and Immunology Research Center, Centre de Recherche du
CHUL and Anatomy and Physiology Department, Faculty of Medicine, Laval
University, Sainte-Foy, Quebec, Canada; and the Institute of Human
Virology, University of Maryland, Baltimore, MD.
Natural killer (NK) cells are large granular lymphocytes capable of
efficient killing of virus-infected and tumor cells in a major
histocompatibility complex-independent manner. The
cytotoxic killing potential of NK cells can be modulated by a variety
of factors, including cytokines such as interleukin-12 (IL-12), IL-15, and interferon (IFN). IL-15 also plays an important role in NK cell
development and survival. Killing of virally infected cells by NK cells
is likely to represent an important antiviral defense mechanism,
especially during the early phase of infection when antigen-specific
immunity has yet to be generated. In the present work, we studied the
potential of IL-15 to act as a modulator of NK cell-mediated antiviral
defense. Our results clearly indicate that IL-15 can curtail infections
by 3 human herpesviruses: Herpes simplex virus type 1, Epstein-Barr
virus, and human herpesvirus 6. The antiviral activity of IL-15 is
dose-, time-, and NK cell-dependent. IL-15-treated NK cells showed an
increased killing potential against a variety of cells, including
virus-infected target cells. Lastly, using highly purified cell
population, we report that IL-15 triggers the synthesis of IFN- from
both CD4+ and NK cells, which can act in both autocrine
and paracrine fashion to modulate NK cells cytotoxic potential. In
conclusion, IL-15 is a cytokine that can contribute to the
establishment of an antiviral state in 2 ways: first by increasing the
killing ability of NK cells and second by stimulating the synthesis and
secretion of IFN.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. H. Kassim, N. K. Rajasagi, B. W. Ritz, S. B. Pruett, E. M. Gardner, R. Chervenak, and S. R. Jennings
Dendritic Cells Are Required for Optimal Activation of Natural Killer Functions following Primary Infection with Herpes Simplex Virus Type 1
J. Virol.,
April 1, 2009;
83(7):
3175 - 3186.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Saghafian-Hedengren, Y. Sundstrom, E. Sohlberg, C. Nilsson, A. Linde, M. Troye-Blomberg, L. Berg, and E. Sverremark-Ekstrom
Herpesvirus Seropositivity in Childhood Associates with Decreased Monocyte-Induced NK Cell IFN-{gamma} Production
J. Immunol.,
February 15, 2009;
182(4):
2511 - 2517.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Gill and A. A. Ashkar
Overexpression of Interleukin-15 Compromises CD4-Dependent Adaptive Immune Responses against Herpes Simplex Virus 2
J. Virol.,
January 15, 2009;
83(2):
918 - 926.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Ahmad, S. El Bassam, P. Cordeiro, and J. Menezes
Requirement of TLR2-mediated signaling for the induction of IL-15 gene expression in human monocytic cells by HSV-1
Blood,
September 15, 2008;
112(6):
2360 - 2368.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Wang, J. W. Holland, A. Carrington, J. Zou, and C. J. Secombes
Molecular and Functional Characterization of IL-15 in Rainbow Trout Oncorhynchus mykiss: A Potent Inducer of IFN-{gamma} Expression in Spleen Leukocytes
J. Immunol.,
August 1, 2007;
179(3):
1475 - 1488.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Gill, K. L. Rosenthal, and A. A. Ashkar
NK and NKT Cell-Independent Contribution of Interleukin-15 to Innate Protection against Mucosal Viral Infection
J. Virol.,
April 1, 2005;
79(7):
4470 - 4478.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Yajima, H. Nishimura, S. Sad, H. Shen, H. Kuwano, and Y. Yoshikai
A Novel Role of IL-15 in Early Activation of Memory CD8+ CTL after Reinfection
J. Immunol.,
March 15, 2005;
174(6):
3590 - 3597.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Liu, J. L. Arbiser, A. Holmgren, G. Klein, and E. Klein
PSK and Trx80 inhibit B-cell growth in EBV-infected cord blood mononuclear cells through T cells activated by the monocyte products IL-15 and IL-12
Blood,
February 15, 2005;
105(4):
1606 - 1613.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. De Bolle, L. Naesens, and E. De Clercq
Update on Human Herpesvirus 6 Biology, Clinical Features, and Therapy
Clin. Microbiol. Rev.,
January 1, 2005;
18(1):
217 - 245.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S. Choi, V. S. Chhabra, Q. H. Nguyen, B. J. Ank, E. R. Stiehm, and R. L. Roberts
Interleukin-15 Enhances Cytotoxicity, Receptor Expression, and Expansion of Neonatal Natural Killer Cells in Long-Term Culture
Clin. Vaccine Immunol.,
September 1, 2004;
11(5):
879 - 888.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Obar, S. G. Crist, E. K. Leung, and E. J. Usherwood
IL-15-Independent Proliferative Renewal of Memory CD8+ T Cells in Latent Gammaherpesvirus Infection
J. Immunol.,
August 15, 2004;
173(4):
2705 - 2714.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. P. Kalberer, U. Siegler, and A. Wodnar-Filipowicz
Human NK cell development in NOD/SCID mice receiving grafts of cord blood CD34+ cells
Blood,
July 1, 2003;
102(1):
127 - 135.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D.H. Dockrell
Human herpesvirus 6: molecular biology and clinical features
J. Med. Microbiol.,
January 1, 2003;
52(1):
5 - 18.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Obata-Onai, S.-i. Hashimoto, N. Onai, M. Kurachi, S. Nagai, K.-i. Shizuno, T. Nagahata, and K. Matsushima
Comprehensive gene expression analysis of human NK cells and CD8+ T lymphocytes
Int. Immunol.,
October 1, 2002;
14(10):
1085 - 1098.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. D. Wilson and A. J. Morgan
Primary Immune Responses by Cord Blood CD4+ T Cells and NK Cells Inhibit Epstein-Barr Virus B-Cell Transformation In Vitro
J. Virol.,
May 15, 2002;
76(10):
5071 - 5081.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Sharif-Askari, L. M. Fawaz, P. Tran, A. Ahmad, and J. Menezes
Interleukin 15-Mediated Induction of Cytotoxic Effector Cells Capable of Eliminating Epstein-Barr Virus-Transformed/Immortalized Lymphocytes in Culture
J Natl Cancer Inst,
November 21, 2001;
93(22):
1724 - 1732.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Yu, M. Hagihara, K. Ando, B. Gansuvd, H. Matsuzawa, T. Tsuchiya, Y. Ueda, H. Inoue, T. Hotta, and S. Kato
Enhancement of Human Cord Blood CD34+ Cell-Derived NK Cell Cytotoxicity by Dendritic Cells
J. Immunol.,
February 1, 2001;
166(3):
1590 - 1600.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. A. Fehniger and M. A. Caligiuri
Interleukin 15: biology and relevance to human disease
Blood,
January 1, 2001;
97(1):
14 - 32.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Goodbourn, L. Didcock, and R. E. Randall
Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures
J. Gen. Virol.,
October 1, 2000;
81(10):
2341 - 2364.
[Full Text]
|
|
|
|
|
|
|
A. Ahmad, E. Sharif-Askari, L. Fawaz, and J. Menezes
Innate Immune Response of the Human Host to Exposure with Herpes Simplex Virus Type 1: In Vitro Control of the Virus Infection by Enhanced Natural Killer Activity via Interleukin-15 Induction
J. Virol.,
August 15, 2000;
74(16):
7196 - 7203.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. P. Perera, C. K. Goldman, and T. A. Waldmann
Comparative assessment of virulence of recombinant vaccinia viruses expressing IL-2 and IL-15 in immunodeficient mice
PNAS,
April 24, 2001;
98(9):
5146 - 5151.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
