|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 94 No. 12 (December 15), 1999:
pp. 4274-4281
Interferon Consensus Sequence Binding Protein and
Interferon Regulatory Factor-4/Pip Form a Complex That
Represses the Expression of the Interferon-Stimulated Gene-15 in
Macrophages
Frank Rosenbauer,
Jeffrey F. Waring,
John Foerster,
Marcus Wietstruk,
Dieter Philipp, and
Ivan Horak
From the Department of Molecular Genetics, Research Institute of
Molecular Pharmacology, and University Hospital Benjamin Franklin, Free
University of Berlin, Berlin, Germany.
Interferon consensus sequence binding protein (ICSBP), a
transcription factor of the interferon (IFN) regulatory factor (IRF) family, binds to the IFN-stimulated response element (ISRE) in the
regulatory region of IFNs and IFN-stimulated genes (ISG). To identify
target genes, which are deregulated by an ICSBP null-mutation in mice
(ICSBP /), we have analyzed transcription of an ISRE-bearing gene,
ISG15. We have found that although ISG15 expression is unchanged in B
cells, it is upregulated in macrophages from ICSBP/ mice. Three
factors, ICSBP, IRF-2, and IRF-4/Pip interact with the ISRE in B cells,
however only ICSBP and IRF-4/Pip were found to bind this sequence in
macrophages of wild-type mice. Although IRF-4 was considered to be a
lymphoid-specific factor, we provide evidence for its role in
macrophage gene regulation. Our results suggest that the formation of
cell-type-specific heteromeric complexes between individual IRFs plays
a crucial role in regulating IFN responses.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
R. Hrdlickova, J. Nehyba, and H. R. Bose Jr.
Regulation of Telomerase Activity by Interferon Regulatory Factors 4 and 8 in Immune Cells
Mol. Cell. Biol.,
February 1, 2009;
29(3):
929 - 941.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Wang, C. H. Lee, C. Qi, P. Tailor, J. Feng, S. Abbasi, T. Atsumi, and H. C. Morse III
IRF8 regulates B-cell lineage specification, commitment, and differentiation
Blood,
November 15, 2008;
112(10):
4028 - 4038.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. H. Lee, M. Melchers, H. Wang, T. A. Torrey, R. Slota, C.-F. Qi, J. Y. Kim, P. Lugar, H. J. Kong, L. Farrington, et al.
Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
J. Exp. Med.,
January 23, 2006;
203(1):
63 - 72.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Wang, R. M. Baron, G. Zhu, M. Joo, J. W. Christman, E. S. Silverman, M. A. Perrella, R. J. Riese, and M. Cernadas
PU.1 Regulates Cathepsin S Expression in Professional APCs
J. Immunol.,
January 1, 2006;
176(1):
275 - 283.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lehtonen, V. Veckman, T. Nikula, R. Lahesmaa, L. Kinnunen, S. Matikainen, and I. Julkunen
Differential Expression of IFN Regulatory Factor 4 Gene in Human Monocyte-Derived Dendritic Cells and Macrophages
J. Immunol.,
November 15, 2005;
175(10):
6570 - 6579.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Negishi, Y. Ohba, H. Yanai, A. Takaoka, K. Honma, K. Yui, T. Matsuyama, T. Taniguchi, and K. Honda
Negative regulation of Toll-like-receptor signaling by IRF-4
PNAS,
November 1, 2005;
102(44):
15989 - 15994.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Honma, H. Udono, T. Kohno, K. Yamamoto, A. Ogawa, T. Takemori, A. Kumatori, S. Suzuki, T. Matsuyama, and K. Yui
Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS
PNAS,
November 1, 2005;
102(44):
16001 - 16006.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Tamura, P. Thotakura, T. S. Tanaka, M. S. H. Ko, and K. Ozato
Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages
Blood,
September 15, 2005;
106(6):
1938 - 1947.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. V. Pedchenko, G. Y. Park, M. Joo, T. S. Blackwell, and J. W. Christman
Inducible binding of PU.1 and interacting proteins to the Toll-like receptor 4 promoter during endotoxemia
Am J Physiol Lung Cell Mol Physiol,
September 1, 2005;
289(3):
L429 - L437.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Suzuki, K. Honma, T. Matsuyama, K. Suzuki, K. Toriyama, I. Akitoyo, K. Yamamoto, T. Suematsu, M. Nakamura, K. Yui, et al.
From the Cover: Critical roles of interferon regulatory factor 4 in CD11bhighCD8{alpha}- dendritic cell development
PNAS,
June 15, 2004;
101(24):
8981 - 8986.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Rosenbauer, K. Wagner, P. Zhang, K.-P. Knobeloch, A. Iwama, and D. G. Tenen
pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1
Blood,
June 1, 2004;
103(11):
4294 - 4301.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Joo, G. Y. Park, J. G. Wright, T. S. Blackwell, M. L. Atchison, and J. W. Christman
Transcriptional Regulation of the Cyclooxygenase-2 Gene in Macrophages by PU.1
J. Biol. Chem.,
February 20, 2004;
279(8):
6658 - 6665.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Liu and S. I. Abrams
Coordinate Regulation of IFN Consensus Sequence-Binding Protein and Caspase-1 in the Sensitization of Human Colon Carcinoma Cells to Fas-Mediated Apoptosis by IFN-{gamma}
J. Immunol.,
June 15, 2003;
170(12):
6329 - 6337.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. O'Reilly, C. M. Quinn, T. El-Shanawany, S. Gordon, and D. R. Greaves
Multiple Ets Factors and Interferon Regulatory Factor-4 Modulate CD68 Expression in a Cell Type-specific Manner
J. Biol. Chem.,
June 6, 2003;
278(24):
21909 - 21919.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Martinez, C. A. Afshari, P. R. Bushel, A. Masuda, T. Takahashi, and N. J. Walker
Differential Toxicogenomic Responses to 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Malignant and Nonmalignant Human Airway Epithelial Cells
Toxicol. Sci.,
October 1, 2002;
69(2):
409 - 423.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Sharma, N. Grandvaux, Y. Mamane, P. Genin, N. Azimi, T. Waldmann, and J. Hiscott
Regulation of IFN Regulatory Factor 4 Expression in Human T Cell Leukemia Virus-I-Transformed T Cells
J. Immunol.,
September 15, 2002;
169(6):
3120 - 3130.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Meraro, M. Gleit-Kielmanowicz, H. Hauser, and B.-Z. Levi
IFN-Stimulated Gene 15 Is Synergistically Activated Through Interactions Between the Myelocyte/Lymphocyte-Specific Transcription Factors, PU.1, IFN Regulatory Factor-8/IFN Consensus Sequence Binding Protein, and IFN Regulatory Factor-4: Characterization of a New Subtype of IFN-Stimulated Response Element
J. Immunol.,
June 15, 2002;
168(12):
6224 - 6231.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kallies, F. Rosenbauer, M. Scheller, K.-P. Knobeloch, and I. Horak
Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein-deficient bone marrow-derived macrophages
Blood,
May 1, 2002;
99(9):
3213 - 3219.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. R. Bose Jr.
Interferon Regulatory Factor 4 Contributes to Transformation of v-Rel-Expressing Fibroblasts
Mol. Cell. Biol.,
October 1, 2001;
21(19):
6369 - 6386.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Marecki, C. J. Riendeau, M. D. Liang, and M. J. Fenton
PU.1 and Multiple IFN Regulatory Factor Proteins Synergize to Mediate Transcriptional Activation of the Human IL-1{{beta}} Gene
J. Immunol.,
June 1, 2001;
166(11):
6829 - 6838.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Matsumoto, K. Hisatake, Y. Nogi, and M. Tsujimoto
Regulation of Receptor Activator of NF-kappa B Ligand-induced Tartrate-resistant Acid Phosphatase Gene Expression by PU.1-interacting Protein/Interferon Regulatory Factor-4. SYNERGISM WITH MICROPHTHALMIA TRANSCRIPTION FACTOR
J. Biol. Chem.,
August 24, 2001;
276(35):
33086 - 33092.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
