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Blood, Vol. 94 No. 3 (August 1), 1999:
pp. 1108-1112
STAT5 Activation by BCR-Abl Contributes to Transformation of K562
Leukemia Cells
Rolf P. de Groot,
Jan A.M. Raaijmakers,
Jan-Willem J. Lammers,
Richard Jove, and
Leo Koenderman
From the Department of Pulmonary Diseases, University Hospital
Utrecht, Utrecht, The Netherlands; and the Molecular Oncology Program,
H. Lee Moffit Cancer Center and Research Institute, University of South
Florida College of Medicine, Tampa, FL.
Signal transducers and activators of transcription (STATs) belong to
a family of transcription factors that were originally identified as
mediators of cytokine-induced gene expression. Recent evidence,
however, has shown that certain members of the STAT family, including
STAT3, are also involved in cellular transformation. Here we show that
STAT5 also plays a role in cellular transformation by the BCR-Abl
oncogene. In BCR-Abl transformed K562 cells, STAT5A and 5B are
constitutively phosphorylated on tyrosine and are transcriptionally active. Moreover, expression of a dominant negative form of STAT5 shows
that active STAT5 is necessary for the growth in soft agar of these
cells. These results show that besides STAT3, STAT5 can also be
involved in cellular transformation.
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