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Blood, Vol. 94 No. 3 (August 1), 1999:
pp. 845-852
Serial Analysis of Gene Expression in Human Monocyte-Derived Dendritic
Cells
Shin-ichi Hashimoto,
Takuji Suzuki,
Hong-Yan Dong,
Shigenori Nagai,
Nobuyuki Yamazaki, and
Kouji Matsushima
From the Department of Molecular Preventive Medicine and CREST,
School of Medicine,The University of Tokyo, Tokyo, Japan.
Dendritic cells (DCs) are professional antigen-presenting cells in
the immune system and can be generated in vitro from hematopoietic progenitor cells in the bone marrow, CD34+ cord blood
cells, precursor cells in the peripheral blood, and blood monocytes by
culturing with granulocyte-macrophage colony-stimulating factor
(GM-CSF), interleukin-4, and tumor necrosis factor- . We have performed serial analysis of gene expression (SAGE) in DCs derived
from human blood monocytes. A total of 58,540 tag
sequences from a DC complementary DNA (cDNA) library represented more
than 17,000 different genes, and these data were compared with SAGE analysis of tags from monocytes (Mo) and GM-CSF-induced macrophages (M ). Many of the genes that were differentially expressed in DCs
were identified as genes encoding proteins related to cell structure
and cell motility. Interestingly, the highly expressed genes in DCs
encode chemokines such as TARC, MDC, and MCP-4, which preferentially
chemoattract Th2-type lymphocytes. Although DCs have been considered to
be very heterogeneous, the identification of specific genes expressed
in human Mo-derived DCs should provide candidate genes to define
subsets of, the function of, and the maturation stage of DCs and
possibly also to diagnose diseases in which DCs play a significant
role, such as autoimmune diseases and neoplasms. This
study represents the first extensive gene expression analysis in any
type of DCs.
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|
|
|
|
|
|
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|
|
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|
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|
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|
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|
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S. Nagai, S.-i. Hashimoto, T. Yamashita, N. Toyoda, T. Satoh, T. Suzuki, and K. Matsushima
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13(3):
367 - 376.
[Abstract]
[Full Text]
[PDF]
|
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|
|
|
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K. Sato, H. Kawasaki, H. Nagayama, M. Enomoto, C. Morimoto, K. Tadokoro, T. Juji, and T. A. Takahashi
Signaling events following chemokine receptor ligation in human dendritic cells at different developmental stages
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February 1, 2001;
13(2):
167 - 179.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kawasaki, H. Takizawa, H. Yoneyama, T. Nakayama, R. Fujisawa, M. Izumizaki, T. Imai, O. Yoshie, I. Homma, K. Yamamoto, et al.
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166(3):
2055 - 2062.
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[PDF]
|
|
|
|
|
|
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T. Suzuki, S.-i. Hashimoto, N. Toyoda, S. Nagai, N. Yamazaki, H.-Y. Dong, J. Sakai, T. Yamashita, T. Nukiwa, and K. Matsushima
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96(7):
2584 - 2591.
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[Full Text]
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|
|
|
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|
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96(6):
2206 - 2214.
[Abstract]
[Full Text]
[PDF]
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|
|
|
|
|
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J.-J. Chen, J. D. Rowley, and S. M. Wang
Generation of longer cDNA fragments from serial analysis of gene expression tags for gene identification
PNAS,
January 4, 2000;
97(1):
349 - 353.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
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F. Le Naour, L. Hohenkirk, A. Grolleau, D. E. Misek, P. Lescure, J. D. Geiger, S. Hanash, and L. Beretta
Profiling Changes in Gene Expression during Differentiation and Maturation of Monocyte-derived Dendritic Cells Using Both Oligonucleotide Microarrays and Proteomics
J. Biol. Chem.,
May 18, 2001;
276(21):
17920 - 17931.
[Abstract]
[Full Text]
[PDF]
|
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