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Blood, Vol. 94 No. 3 (August 1), 1999:
pp. 909-913
The Incidence of Idiopathic Thrombocytopenic Purpura in Adults
Increases With Age
Henrik Frederiksen and
Kai Schmidt
From the Department of Hematology, Odense University Hospital,
Odense, Denmark.
With the aim of determining the incidence of idiopathic
thrombocytopenic purpura (ITP) in adults, we searched all adult ITP patients diagnosed from April 1, 1973 to December 31, 1995 in the
County of Funen in Denmark. This county comprises 9% of the total
Danish adult population. A total of 221 patients fulfilled the
inclusion criteria, yielding an annual standardized incidence rate of
2.68 per 100,000. The median age of the patient population was 56 years, and the female to male ratio was 1.7. Changing the platelet
count cut-off point from 100 × 109/L to 50 × 109/L changed the incidence rate to 2.25 per 100,000. Comparing patients less and more than 60 years old, the incidence rate
more than doubled and the sex difference was eliminated in the older
age group. These two age groups were almost identical regarding
platelet count at diagnosis and number of asymptomatic cases. The
incidence rate increased in the study period. This increase in
particular involved asymptomatic patients and old males who were both
symptomatic or not symptomatic. Including additional patients
identified by a questionnaire study of the contribution from the
primary care physicians and the practicing specialists in the second
half of the study period, a reliable estimate of the annual ITP
incidence in Danish adults, using a platelet concentration cut-off
point of 50 × 109/L, is 3.2 per 100,000 persons.
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