|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 94 No. 3 (August 1), 1999:
pp. 940-949
Hyaluronate-Enhanced Hematopoiesis: Two Different Receptors Trigger the
Release of Interleukin-1 and Interleukin-6 From Bone Marrow
Macrophages
Sophia Khaldoyanidi,
Jürgen Moll,
Svetlana Karakhanova,
Peter Herrlich, and
Helmut Ponta
From Forschungszentrum Karlsruhe, Institute of Genetics,
Karlsruhe, Germany.
The glycosaminoglycan hyaluronate (HA) is part of the extracellular
environment in bone marrow. We show here that HA activates signal
transduction cascades important for hemopoiesis. In myeloid and
lymphoid long-term bone marrow cultures (LTBMC), treatment with
hyaluronidase (HA'ase) results in reduced production of both progenitor and mature cells. Exogeneous HA added to LTBMC had the
opposite effect: it enhanced hematopoiesis. The effect of HA is mediated through two different HA receptors on bone marrow macrophage-like cells, one of which is CD44 while the other is unknown.
HA induces bone marrow macrophages to secrete IL-1 (CD44-dependent) and IL-6 (CD44-independent). The two receptors address different signal
transduction pathways: CD44 links to a pathway activating p38 protein
kinase while the other yet unknown receptor induces Erk activity. There
was no difference of the effect of HA and HA'ase on hematopoiesis in
LTBMC and on cytokine production by macrophages in CD44-deficient mice
compared with wild-type mice, indicating that the CD44 hyaluronate
receptor and its signal transduction can be compensated for. Our data
suggest a regulatory role for the extracellular matrix component HA in
hematopoiesis and show the induction of signal transduction by HA receptors.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. V. Kyosseva, E. N. Harris, and P. H. Weigel
The Hyaluronan Receptor for Endocytosis Mediates Hyaluronan-dependent Signal Transduction via Extracellular Signal-regulated Kinases
J. Biol. Chem.,
May 30, 2008;
283(22):
15047 - 15055.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Wimmer, S. K. Khaldoyanidi, M. Judex, N. Serobyan, R. G. DiScipio, and I. U. Schraufstatter
CCL18/PARC stimulates hematopoiesis in long-term bone marrow cultures indirectly through its effect on monocytes
Blood,
December 1, 2006;
108(12):
3722 - 3729.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Sconocchia, H. Fujiwara, K. Rezvani, K. Keyvanfar, F. El Ouriaghli, M. Grube, J. Melenhorst, N. Hensel, and A. J. Barrett
G-CSF-mobilized CD34+ cells cultured in interleukin-2 and stem cell factor generate a phenotypically novel monocyte
J. Leukoc. Biol.,
December 1, 2004;
76(6):
1214 - 1219.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Y. Matrosova, I. A. Orlovskaya, N. Serobyan, and S. K. Khaldoyanidi
Hyaluronic Acid Facilitates the Recovery of Hematopoiesis following 5-Fluorouracil Administration
Stem Cells,
July 1, 2004;
22(4):
544 - 555.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Esnault and J. S. Malter
Hyaluronic Acid or TNF-{alpha} Plus Fibronectin Triggers Granulocyte Macrophage-Colony-Stimulating Factor mRNA Stabilization in Eosinophils Yet Engages Differential Intracellular Pathways and mRNA Binding Proteins
J. Immunol.,
December 15, 2003;
171(12):
6780 - 6787.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Khaldoyanidi, S. Karakhanova, J. Sleeman, P. Herrlich, and H. Ponta
CD44 variant-specific antibodies trigger hemopoiesis by selective release of cytokines from bone marrow macrophages
Blood,
May 13, 2002;
99(11):
3955 - 3961.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. A. Turley, P. W. Noble, and L. Y. W. Bourguignon
Signaling Properties of Hyaluronan Receptors
J. Biol. Chem.,
February 8, 2002;
277(7):
4589 - 4592.
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Christ, U. Gunthert, D.-S. Schmidt, and M. Zoller
Allogeneic reconstitution after nonmyeloablative conditioning: mitigation of graft-versus-host and host-versus-graft reactivity by anti-CD44v6
J. Leukoc. Biol.,
January 1, 2002;
71(1):
33 - 46.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R.-S. Charrad, Z. Gadhoum, J. Qi, A. Glachant, M. Allouche, C. Jasmin, C. Chomienne, and F. Smadja-Joffe
Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines
Blood,
January 1, 2002;
99(1):
290 - 299.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Termeer, H. Johannsen, T. Braun, A. Renkl, T. Ahrens, R. W. Denfeld, M. B. Lappin, J. M. Weiss, and J. C. Simon
The role of CD44 during CD40 ligand-induced dendritic cell clustering and maturation
J. Leukoc. Biol.,
November 1, 2001;
70(5):
715 - 722.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Khaldoyanidi, L. Sikora, I. Orlovskaya, V. Matrosova, V. Kozlov, and P. Sriramarao
Correlation between nicotine-induced inhibition of hematopoiesis and decreased CD44 expression on bone marrow stromal cells
Blood,
July 15, 2001;
98(2):
303 - 312.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Horton, M. A. Olman, C. Bao, K. E. White, A. M. K. Choi, B.-Y. Chin, P. W. Noble, and C. J. Lowenstein
Regulation of plasminogen activator inhibitor-1 and urokinase by hyaluronan fragments in mouse macrophages
Am J Physiol Lung Cell Mol Physiol,
October 1, 2000;
279(4):
L707 - L715.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. E. Mummert, M. Mohamadzadeh, D. I. Mummert, N. Mizumoto, and A. Takashima
Development of a Peptide Inhibitor of Hyaluronan-mediated Leukocyte Trafficking
J. Exp. Med.,
September 11, 2000;
192(6):
769 - 780.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Bruno, M. Fabbi, M. Tiso, B. Santamaria, F. Ghiotto, D. Saverino, C. Tenca, D. Zarcone, S. Ferrini, E. Ciccone, et al.
Cell activation via CD44 occurs in advanced stages of squamous cell carcinogenesis
Carcinogenesis,
May 1, 2000;
21(5):
893 - 900.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Vincent, M. Jourdan, M.-S. Sy, B. Klein, and N. Mechti
Hyaluronic Acid Induces Survival and Proliferation of Human Myeloma Cells through an Interleukin-6-mediated Pathway Involving the Phosphorylation of Retinoblastoma Protein
J. Biol. Chem.,
April 27, 2001;
276(18):
14728 - 14736.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
