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Blood, Vol. 94 No. 5 (September 1), 1999:
pp. 1545-1549
Inheritance of Chromosomally Integrated Human Herpesvirus 6 DNA
Masanori Daibata,
Takahiro Taguchi,
Yuiko Nemoto,
Hirokuni Taguchi, and
Isao Miyoshi
From the Departments of Medicine and Anatomy, Kochi Medical School,
Kochi, Japan.
Human herpesvirus 6 (HHV-6) genome has been detected in several
human lymphoproliferative disorders with no signs of active viral
infection, and found to be integrated into chromosomes in some cases.
We previously reported a woman with HHV-6-infected Burkitt's
lymphoma. Fluorescence in situ hybridization showed that the viral
genome was integrated into the long arm of chromosome 22 (22q13). The
patient's asymptomatic husband also carried HHV-6 DNA integrated at
chromosome locus 1q44. To assess the possibility of chromosomal
transmission of HHV-6 DNA, we looked for HHV-6 DNA in the peripheral
blood of their daughter. She had HHV-6 DNA on both chromosomes 22q13
and 1q44, identical to the site of viral integration of her mother and
father, respectively. The findings suggested that her viral genomes
were inherited chromosomally from both parents. The 3 family members
were all seropositive for HHV-6, but showed no serological signs of
active infection. To confirm the presence of HHV-6 DNA sequences, we
performed polymerase chain reaction (PCR) with 7 distinct primer pairs
that target different regions of HHV-6. The viral sequences were
consistently detected by single-step PCR in all 3 family members. We
propose a novel latent form for HHV-6, in which integrated viral genome can be chromosomally transmitted. The possible role of the
chromosomally integrated HHV-6 in the pathogenesis of
lymphoproliferative diseases remains to be explained.
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