|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 94 No. 6 (September 15), 1999:
pp. 1848-1854
Unmutated Ig VH Genes Are Associated With a More
Aggressive Form of Chronic Lymphocytic Leukemia
Terry J. Hamblin,
Zadie Davis,
Anne Gardiner,
David G. Oscier, and
Freda K. Stevenson
From the Department of Haematology, Royal Bournemouth Hospital,
Bournemouth, UK; and the Molecular Immunology Department, Tenovus
Research Laboratory, Southampton General Hospital, Southampton,
UK.
Despite having several characteristics of naïve B cells,
chronic lymphocytic leukemia (CLL) cells have been shown in some cases
to have somatically mutated Ig variable region genes, indicating that
the cell of origin has passed through the germinal center. A previous
study of patients with CLL found an association between lack of somatic
mutation and trisomy 12 and, therefore, possibly with a less favorable
prognosis. We have sequenced the Ig VH genes of the tumor
cells of 84 patients with CLL and correlated our findings with clinical
features. A total of 38 cases (45.2%) showed  98% sequence
homology with the nearest germline VH gene; 46 cases
(54.8%) showed >2% somatic mutation. Unmutated VH genes were significantly associated with V1-69 and D3-3 usage, with atypical
morphology; isolated trisomy 12, advanced stage and progressive disease. Survival was significantly worse for patients with unmutated VH genes irrespective of stage. Median survival for stage A
patients with unmutated VH genes was 95 months compared
with 293 months for patients whose tumors had mutated VH
genes (P = .0008). The simplest explanation is that
CLL comprises 2 different diseases with different clinical courses.
One, arising from a memory B cell, has a benign course, the other,
arising from a naïve B cell, is more malignant.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Letters in Blood Online:
-
Expression of unmutated VH genes is a detrimental prognostic factor in chronic lymphocytic leukemia
- Karim Maloum, Frédéric Davi, Hélène Merle-Béral, Otto Pritsch, Christian Magnac, Françoise Vuillier, Guillaume Dighiero, Xavier Troussard, Francesca F. Mauro, and Jacques Bénichou
Blood 2000 96: 377-379.
[Full Text]
[PDF]
-
CD38 expression is a poor predictor for VH gene mutational status and prognosis in chronic lymphocytic leukemia
- Ulf Thunberg, Anna Johnson, Göran Roos, Ingrid Thörn, Gerard Tobin, Jan Sällström, Christer Sundström, Richard Rosenquist, Franco Fais, Fabio Ghiotto, Rajendra Damle, Tarun Wasil, Nicholas Chiorazzi, Simona Zupo, and Manlio Ferrarini
Blood 2001 97: 1892-1894.
[Full Text]
[PDF]
-
CD38 expression and Ig VH gene mutation in B-cell chronic lymphocytic leukemia
- Zoltan Matrai, Ke Lin, Michael Dennis, Paul Sherrington, Mirko Zuzel, Andrew R Pettitt, and John C. Cawley
Blood 2001 97: 1902.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
L.-A. Sutton, E. Kostareli, A. Hadzidimitriou, N. Darzentas, A. Tsaftaris, A. Anagnostopoulos, R. Rosenquist, and K. Stamatopoulos
Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen
Blood,
November 12, 2009;
114(20):
4460 - 4468.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Sharma and A. Lichtenstein
Aberrant splicing of the E-cadherin transcript is a novel mechanism of gene silencing in chronic lymphocytic leukemia cells
Blood,
November 5, 2009;
114(19):
4179 - 4185.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Visone, L. Z. Rassenti, A. Veronese, C. Taccioli, S. Costinean, B. D. Aguda, S. Volinia, M. Ferracin, J. Palatini, V. Balatti, et al.
Karyotype-specific microRNA signature in chronic lymphocytic leukemia
Blood,
October 29, 2009;
114(18):
3872 - 3879.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Seiler, M. Woelfle, S. Yancopoulos, R. Catera, W. Li, K. Hatzi, C. Moreno, M. Torres, S. Paul, H. Dohner, et al.
Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells
Blood,
October 22, 2009;
114(17):
3615 - 3624.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. D. Shanafelt, N. E. Kay, K. G. Rabe, T. G. Call, C. S. Zent, K. Maddocks, G. Jenkins, D. F. Jelinek, W. G. Morice, J. Boysen, et al.
Brief Report: Natural History of Individuals With Clinically Recognized Monoclonal B-Cell Lymphocytosis Compared With Patients With Rai 0 Chronic Lymphocytic Leukemia
J. Clin. Oncol.,
August 20, 2009;
27(24):
3959 - 3963.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. D. Shanafelt, T. G. Call, C. S. Zent, B. LaPlant, D. A. Bowen, M. Roos, C. R. Secreto, A. K. Ghosh, B. F. Kabat, M.-J. Lee, et al.
Phase I Trial of Daily Oral Polyphenon E in Patients With Asymptomatic Rai Stage 0 to II Chronic Lymphocytic Leukemia
J. Clin. Oncol.,
August 10, 2009;
27(23):
3808 - 3814.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Bene and J. S. Kaeda
How and why minimal residual disease studies are necessary in leukemia: a review from WP10 and WP12 of the European LeukaemiaNet
Haematologica,
August 1, 2009;
94(8):
1135 - 1150.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. P. Quiroga, K. Balakrishnan, A. V. Kurtova, M. Sivina, M. J. Keating, W. G. Wierda, V. Gandhi, and J. A. Burger
B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406
Blood,
July 30, 2009;
114(5):
1029 - 1037.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Dagklis, C. Fazi, C. Sala, V. Cantarelli, C. Scielzo, R. Massacane, D. Toniolo, F. Caligaris-Cappio, K. Stamatopoulos, and P. Ghia
The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring
Blood,
July 2, 2009;
114(1):
26 - 32.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Buchner, S. Fuchs, G. Prinz, D. Pfeifer, K. Bartholome, M. Burger, N. Chevalier, L. Vallat, J. Timmer, J. G. Gribben, et al.
Spleen Tyrosine Kinase Is Overexpressed and Represents a Potential Therapeutic Target in Chronic Lymphocytic Leukemia
Cancer Res.,
July 1, 2009;
69(13):
5424 - 5432.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Rossi, V. Spina, M. Cerri, S. Rasi, C. Deambrogi, L. De Paoli, L. Laurenti, R. Maffei, F. Forconi, F. Bertoni, et al.
Stereotyped B-Cell Receptor Is an Independent Risk Factor of Chronic Lymphocytic Leukemia Transformation to Richter Syndrome
Clin. Cancer Res.,
July 1, 2009;
15(13):
4415 - 4422.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. G. Johnson, P. D. Sherrington, A. Carter, K. Lin, T. Liloglou, J. K. Field, and A. R. Pettitt
A Novel Type of p53 Pathway Dysfunction in Chronic Lymphocytic Leukemia Resulting from Two Interacting Single Nucleotide Polymorphisms within the p21 Gene
Cancer Res.,
June 15, 2009;
69(12):
5210 - 5217.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Deaglio and F. Malavasi
Chronic lymphocytic leukemia microenvironment: shifting the balance from apoptosis to proliferation
Haematologica,
June 1, 2009;
94(6):
752 - 756.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Stamatopoulos, B. Haibe-Kains, C. Equeter, N. Meuleman, A. Soree, C. De Bruyn, D. Hanosset, D. Bron, P. Martiat, and L. Lagneaux
Gene expression profiling reveals differences in microenvironment interaction between patients with chronic lymphocytic leukemia expressing high versus low ZAP70 mRNA
Haematologica,
June 1, 2009;
94(6):
790 - 799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Stamatopoulos, N. Meuleman, B. Haibe-Kains, P. Saussoy, E. Van Den Neste, L. Michaux, P. Heimann, P. Martiat, D. Bron, and L. Lagneaux
microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification
Blood,
May 21, 2009;
113(21):
5237 - 5245.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. C. Yin, K. I-C. Lin, R. P. Ketterling, R. A. Knudson, L. J. Medeiros, L. L. Barron, Y. O. Huh, R. Luthra, M. J. Keating, and L. V. Abruzzo
Chronic Lymphocytic Leukemia With t(2;14)(p16;q32) Involves the BCL11A and IgH Genes and Is Associated With Atypical Morphologic Features and Unmutated IgVH Genes
Am J Clin Pathol,
May 1, 2009;
131(5):
663 - 670.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Crowther-Swanepoel and R. S. Houlston
The molecular basis of familial chronic lymphocytic leukemia
Haematologica,
May 1, 2009;
94(5):
606 - 609.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. KALPADAKIS, G. A. PANGALIS, E. DIMITRIADOU, M. K. ANGELOPOULOU, M. P. SIAKANTARIS, M.-C. KYRTSONIS, M. XIMERIS, T. TZENOU, S. SAHANAS, X. YIAKOUMIS, et al.
Mutation Analysis of IgVH Genes in Splenic Marginal Zone Lymphomas: Correlation with Clinical Characteristics and Outcome
Anticancer Res,
May 1, 2009;
29(5):
1811 - 1816.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Farina, C. Carniti, A. Dodero, A. Vendramin, A. Raganato, F. Spina, F. Patriarca, F. Narni, F. Benedetti, A. Olivieri, et al.
Qualitative and quantitative polymerase chain reaction monitoring of minimal residual disease in relapsed chronic lymphocytic leukemia: early assessment can predict long-term outcome after reduced intensity allogeneic transplantation
Haematologica,
May 1, 2009;
94(5):
654 - 662.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. D. Shanafelt, N. E. Kay, G. Jenkins, T. G. Call, C. S. Zent, D. F. Jelinek, W. G. Morice, J. Boysen, L. Zakko, S. Schwager, et al.
B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcome
Blood,
April 30, 2009;
113(18):
4188 - 4196.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. I. Lin, C. S. Tam, M. J. Keating, W. G. Wierda, S. O'Brien, S. Lerner, K. R. Coombes, E. Schlette, A. Ferrajoli, L. L. Barron, et al.
Relevance of the immunoglobulin VH somatic mutation status in patients with chronic lymphocytic leukemia treated with fludarabine, cyclophosphamide, and rituximab (FCR) or related chemoimmunotherapy regimens
Blood,
April 2, 2009;
113(14):
3168 - 3171.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Landgren, M. Albitar, W. Ma, F. Abbasi, R. B. Hayes, P. Ghia, G. E. Marti, and N. E. Caporaso
B-Cell Clones as Early Markers for Chronic Lymphocytic Leukemia
N. Engl. J. Med.,
February 12, 2009;
360(7):
659 - 667.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Hewamana, T. T. Lin, C. Rowntree, K. Karunanithi, G. Pratt, R. Hills, C. Fegan, P. Brennan, and C. Pepper
Rel A Is an Independent Biomarker of Clinical Outcome in Chronic Lymphocytic Leukemia
J. Clin. Oncol.,
February 10, 2009;
27(5):
763 - 769.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Grubor, A. Krasnitz, J. E. Troge, J. L. Meth, B. Lakshmi, J. T. Kendall, B. Yamrom, G. Alex, D. Pai, N. Navin, et al.
Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA)
Blood,
February 5, 2009;
113(6):
1294 - 1303.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. BOELENS, S. LUST, B. VANHOECKE, and F. OFFNER
Chronic Lymphocytic Leukaemia
Anticancer Res,
February 1, 2009;
29(2):
605 - 615.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. J. Lewintre, C. R. Martin, C. G. Ballesteros, D. Montaner, R. F. Rivera, J. R. Mayans, and J. Garcia-Conde
Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia
Haematologica,
February 1, 2009;
94(2):
280 - 284.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Hadzidimitriou, N. Darzentas, F. Murray, T. Smilevska, E. Arvaniti, C. Tresoldi, A. Tsaftaris, N. Laoutaris, A. Anagnostopoulos, F. Davi, et al.
Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia
Blood,
January 8, 2009;
113(2):
403 - 411.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Sargent, D. Jones, L. V. Abruzzo, H. Yao, J. Bonderover, M. Cisneros, W. G. Wierda, M. J. Keating, and R. Luthra
Customized Oligonucleotide Array-Based Comparative Genomic Hybridization as a Clinical Assay for Genomic Profiling of Chronic Lymphocytic Leukemia
J. Mol. Diagn.,
January 1, 2009;
11(1):
25 - 34.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Kipps
Chronic Lymphocytic Leukemia: Advances in Assessing Prognosis and Therapy
ASCO Educational Book,
January 1, 2009;
2009(1):
385 - 393.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. C. Chu, R. Catera, K. Hatzi, X.-J. Yan, L. Zhang, X. B. Wang, H. M. Fales, S. L. Allen, J. E. Kolitz, K. R. Rai, et al.
Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA
Blood,
December 15, 2008;
112(13):
5122 - 5129.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Trentin, M. Frasson, A. Donella-Deana, F. Frezzato, M. A. Pagano, E. Tibaldi, C. Gattazzo, R. Zambello, G. Semenzato, and A. M. Brunati
Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia
Blood,
December 1, 2008;
112(12):
4665 - 4674.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Pepper, T. T. Lin, G. Pratt, S. Hewamana, P. Brennan, L. Hiller, R. Hills, R. Ward, J. Starczynski, B. Austen, et al.
Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers
Blood,
November 1, 2008;
112(9):
3807 - 3817.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Rossi, A. Zucchetto, F. M. Rossi, D. Capello, M. Cerri, C. Deambrogi, S. Cresta, S. Rasi, L. De Paoli, C. L. Bodoni, et al.
CD49d expression is an independent risk factor of progressive disease in early stage chronic lymphocytic leukemia
Haematologica,
October 1, 2008;
93(10):
1575 - 1579.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Caligaris-Cappio and P. Ghia
Novel Insights in Chronic Lymphocytic Leukemia: Are We Getting Closer to Understanding the Pathogenesis of the Disease?
J. Clin. Oncol.,
September 20, 2008;
26(27):
4497 - 4503.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Reinoso-Martin, E. Jantus-Lewintre, C. G. Ballesteros, C. B. Campos, J. R. M. Ferrer, and J. Garcia-Conde
ZAP-70 mRNA expression provides clinically valuable information in early-stage chronic lymphocytic leukemia
Haematologica,
September 1, 2008;
93(9):
1422 - 1424.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Kujawski, P. Ouillette, H. Erba, C. Saddler, A. Jakubowiak, M. Kaminski, K. Shedden, and S. N. Malek
Genomic complexity identifies patients with aggressive chronic lymphocytic leukemia
Blood,
September 1, 2008;
112(5):
1993 - 2003.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Z. Rassenti, S. Jain, M. J. Keating, W. G. Wierda, M. R. Grever, J. C. Byrd, N. E. Kay, J. R. Brown, J. G. Gribben, D. S. Neuberg, et al.
Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia
Blood,
September 1, 2008;
112(5):
1923 - 1930.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Tam, S. O'Brien, W. Wierda, H. Kantarjian, S. Wen, K.-A. Do, D. A. Thomas, J. Cortes, S. Lerner, and M. J. Keating
Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia
Blood,
August 15, 2008;
112(4):
975 - 980.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Veldurthy, M. Patz, S. Hagist, C. P. Pallasch, C.-M. Wendtner, M. Hallek, and G. Krause
The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes
Blood,
August 15, 2008;
112(4):
1443 - 1452.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Rawstron, F. L. Bennett, S. J.M. O'Connor, M. Kwok, J. A.L. Fenton, M. Plummer, R. de Tute, R. G. Owen, S. J. Richards, A. S. Jack, et al.
Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia
N. Engl. J. Med.,
August 7, 2008;
359(6):
575 - 583.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Dighiero
Monoclonal B-Cell Lymphocytosis -- A Frequent Premalignant Condition
N. Engl. J. Med.,
August 7, 2008;
359(6):
638 - 640.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Tracey, M. Aggarwal, M. Garcia-Cosio, R. Villuendas, P. Algara, M. Sanchez-Beato, A. Sanchez-Aguilera, J. F. Garcia, A. Rodriguez, F. I. Camacho, et al.
Somatic hypermutation signature in B-cell low-grade lymphomas
Haematologica,
August 1, 2008;
93(8):
1186 - 1194.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Guarini, S. Chiaretti, S. Tavolaro, R. Maggio, N. Peragine, F. Citarella, M. R. Ricciardi, S. Santangelo, M. Marinelli, M. S. De Propris, et al.
BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgVH unmutated chronic lymphocytic leukemia (CLL) cells
Blood,
August 1, 2008;
112(3):
782 - 792.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Hamblin
Ligandless receptors find a role
Blood,
July 1, 2008;
112(1):
2 - 3.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Muzio, B. Apollonio, C. Scielzo, M. Frenquelli, I. Vandoni, V. Boussiotis, F. Caligaris-Cappio, and P. Ghia
Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy
Blood,
July 1, 2008;
112(1):
188 - 195.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. J. Li, S. Ding, J. Pan, M. A. Shakhmatov, E. Kashentseva, J. Wu, Y. Li, S.-j. Soong, N. Chiorazzi, and R. S. Davis
FCRL2 expression predicts IGHV mutation status and clinical progression in chronic lymphocytic leukemia
Blood,
July 1, 2008;
112(1):
179 - 187.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hallek, B. D. Cheson, D. Catovsky, F. Caligaris-Cappio, G. Dighiero, H. Dohner, P. Hillmen, M. J. Keating, E. Montserrat, K. R. Rai, et al.
Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
Blood,
June 15, 2008;
111(12):
5446 - 5456.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Aydin, D. Rossi, L. Bergui, G. D'Arena, E. Ferrero, L. Bonello, P. Omede, D. Novero, F. Morabito, A. Carbone, et al.
CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome?
Blood,
June 15, 2008;
111(12):
5646 - 5653.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. E. M. Patten, A. G. S. Buggins, J. Richards, A. Wotherspoon, J. Salisbury, G. J. Mufti, T. J. Hamblin, and S. Devereux
CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment
Blood,
May 15, 2008;
111(10):
5173 - 5181.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. M. Ghia, S. Jain, G. F. Widhopf II, L. Z. Rassenti, M. J. Keating, W. G. Wierda, J. G. Gribben, J. R. Brown, K. R. Rai, J. C. Byrd, et al.
Use of IGHV3-21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post-germinal center leukemogenic selection
Blood,
May 15, 2008;
111(10):
5101 - 5108.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Friedrichs, S. Siegel, M. Kloess, A. Barsoum, J. Coggin Jr., J. Rohrer, I. Jakob, M. Tiemann, K. Heidorn, C. Schulte, et al.
Humoral Immune Responses against the Immature Laminin Receptor Protein Show Prognostic Significance in Patients with Chronic Lymphocytic Leukemia
J. Immunol.,
May 1, 2008;
180(9):
6374 - 6384.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Hewamana, S. Alghazal, T. T. Lin, M. Clement, C. Jenkins, M. L. Guzman, C. T. Jordan, S. Neelakantan, P. A. Crooks, A. K. Burnett, et al.
The NF-{kappa}B subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target
Blood,
May 1, 2008;
111(9):
4681 - 4689.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O V Moshynska and A Saxena
Clonal relationship between Hashimoto thyroiditis and thyroid lymphoma
J. Clin. Pathol.,
April 1, 2008;
61(4):
438 - 444.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lanemo Myhrinder, E. Hellqvist, E. Sidorova, A. Soderberg, H. Baxendale, C. Dahle, K. Willander, G. Tobin, E. Backman, O. Soderberg, et al.
A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies
Blood,
April 1, 2008;
111(7):
3838 - 3848.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. F. Widhopf II, C. J. Goldberg, T. L. Toy, L. Z. Rassenti, W. G. Wierda, J. C. Byrd, M. J. Keating, J. G. Gribben, K. R. Rai, and T. J. Kipps
Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3
Blood,
March 15, 2008;
111(6):
3137 - 3144.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Cutrona, M. Colombo, S. Matis, M. Fabbi, M. Spriano, V. Callea, E. Vigna, M. Gentile, S. Zupo, N. Chiorazzi, et al.
Clonal heterogeneity in chronic lymphocytic leukemia cells: superior response to surface IgM cross-linking in CD38, ZAP-70-positive cells
Haematologica,
March 1, 2008;
93(3):
413 - 422.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. G. Agrawal, F.-T. Liu, C. Wiseman, S. Shirali, H. Liu, D. Lillington, M.-Q. Du, D. Syndercombe-Court, A. C. Newland, J. G. Gribben, et al.
Increased proteasomal degradation of Bax is a common feature of poor prognosis chronic lymphocytic leukemia
Blood,
March 1, 2008;
111(5):
2790 - 2796.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Roos, A. Krober, P. Grabowski, D. Kienle, A. Buhler, H. Dohner, R. Rosenquist, and S. Stilgenbauer
Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia
Blood,
February 15, 2008;
111(4):
2246 - 2252.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Gachard, A. Salviat, C. Boutet, C. Arnoulet, F. Durrieu, B. Lenormand, S. Lepretre, S. Olschwang, F. Jardin, M. Lafage-Pochitaloff, et al.
Multicenter study of ZAP-70 expression in patients with B-cell chronic lymphocytic leukemia using an optimized flow cytometry method
Haematologica,
February 1, 2008;
93(2):
215 - 223.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Murray, N. Darzentas, A. Hadzidimitriou, G. Tobin, M. Boudjogra, C. Scielzo, N. Laoutaris, K. Karlsson, F. Baran-Marzsak, A. Tsaftaris, et al.
Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis
Blood,
February 1, 2008;
111(3):
1524 - 1533.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Saddler, P. Ouillette, L. Kujawski, S. Shangary, M. Talpaz, M. Kaminski, H. Erba, K. Shedden, S. Wang, and S. N. Malek
Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia
Blood,
February 1, 2008;
111(3):
1584 - 1593.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. S. Sellick, R. Wade, S. Richards, D. G. Oscier, D. Catovsky, and R. S. Houlston
Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis
Blood,
February 1, 2008;
111(3):
1625 - 1633.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Baskar, K. Y. Kwong, T. Hofer, J. M. Levy, M. G. Kennedy, E. Lee, L. M. Staudt, W. H. Wilson, A. Wiestner, and C. Rader
Unique Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Human B-Cell Chronic Lymphocytic Leukemia
Clin. Cancer Res.,
January 15, 2008;
14(2):
396 - 404.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. G. Longo, L. Laurenti, S. Gobessi, S. Sica, G. Leone, and D. G. Efremov
The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells
Blood,
January 15, 2008;
111(2):
846 - 855.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Gattei, P. Bulian, M. I. Del Principe, A. Zucchetto, L. Maurillo, F. Buccisano, R. Bomben, M. Dal-Bo, F. Luciano, F. M. Rossi, et al.
Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia
Blood,
January 15, 2008;
111(2):
865 - 873.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. W. Hauswirth and U. Jager
Impact of cytogenetic and molecular prognostic markers on the clinical management of chronic lymphocytic leukemia
Haematologica,
January 1, 2008;
93(1):
14 - 19.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Kipps
Chronic Lymphocytic Leukemia: Prognostic Markers and Revised Criteria for Treatment and Response Assessment
ASCO Educational Book,
January 1, 2008;
2008(1):
286 - 290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. G. Gribben
The Role of Stem Cell Transplantation in Chronic Lymphocytic Leukemia
ASCO Educational Book,
January 1, 2008;
2008(1):
291 - 296.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. N. Damle, S. Temburni, C. Calissano, S. Yancopoulos, T. Banapour, C. Sison, S. L. Allen, K. R. Rai, and N. Chiorazzi
CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells
Blood,
November 1, 2007;
110(9):
3352 - 3359.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Willimott, M. Baou, S. Huf, S. Deaglio, and S. D. Wagner
Regulation of CD38 in proliferating chronic lymphocytic leukemia cells stimulated with CD154 and interleukin-4
Haematologica,
October 1, 2007;
92(10):
1359 - 1366.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Stamatopoulos, N. Meuleman, B. Haibe-Kains, H. Duvillier, M. Massy, P. Martiat, D. Bron, and L. Lagneaux
Quantification of ZAP70 mRNA in B Cells by Real-Time PCR Is a Powerful Prognostic Factor in Chronic Lymphocytic Leukemia
Clin. Chem.,
October 1, 2007;
53(10):
1757 - 1766.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Durig, P. Ebeling, F. Grabellus, U. R. Sorg, M. Mollmann, P. Schutt, J. Gothert, L. Sellmann, S. Seeber, M. Flasshove, et al.
A Novel Nonobese Diabetic/Severe Combined Immunodeficient Xenograft Model for Chronic Lymphocytic Leukemia Reflects Important Clinical Characteristics of the Disease
Cancer Res.,
September 15, 2007;
67(18):
8653 - 8661.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Stilgenbauer, S. Sander, L. Bullinger, A. Benner, E. Leupolt, D. Winkler, A. Krober, D. Kienle, P. Lichter, and H. Dohner
Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival
Haematologica,
September 1, 2007;
92(9):
1242 - 1245.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. V. Abruzzo, L. L. Barron, K. Anderson, R. J. Newman, W. G. Wierda, S. O'Brien, A. Ferrajoli, M. Luthra, S. Talwalkar, R. Luthra, et al.
Identification and Validation of Biomarkers of IgVH Mutation Status in Chronic Lymphocytic Leukemia Using Microfluidics Quantitative Real-Time Polymerase Chain Reaction Technology
J. Mol. Diagn.,
September 1, 2007;
9(4):
546 - 555.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. A. Gaeta, H. R. Malming, K. J.L. Jackson, M. E. Bain, P. Wilson, and A. M. Collins
iHMMune-align: hidden Markov model-based alignment and identification of germline genes in rearranged immunoglobulin gene sequences
Bioinformatics,
July 1, 2007;
23(13):
1580 - 1587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Sabattini, R. Orduz, C. Campidelli, P. L. Zinzani, V. Callea, S. Zupo, G. Cutrona, F. Morabito, M. Ferrarini, and S. Pileri
B cell chronic lymphocytic leukaemia/small lymphocytic lymphoma: role of ZAP70 determination on bone marrow biopsy specimens
J. Clin. Pathol.,
June 1, 2007;
60(6):
627 - 632.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Josefsson, C. H. Geisler, H. Leffers, J. H. Petersen, M. K. Andersen, J. Jurlander, and A. M. Buhl
CLLU1 expression analysis adds prognostic information to risk prediction in chronic lymphocytic leukemia
Blood,
June 1, 2007;
109(11):
4973 - 4979.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. G. Wierda, S. O'Brien, X. Wang, S. Faderl, A. Ferrajoli, K.-A. Do, J. Cortes, D. Thomas, G. Garcia-Manero, C. Koller, et al.
Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia
Blood,
June 1, 2007;
109(11):
4679 - 4685.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Ian Mockridge, K. N. Potter, I. Wheatley, L. A. Neville, G. Packham, and F. K. Stevenson
Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status
Blood,
May 15, 2007;
109(10):
4424 - 4431.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. D. Vallat, Y. Park, C. Li, and J. G. Gribben
Temporal genetic program following B-cell receptor cross-linking: altered balance between proliferation and death in healthy and malignant B cells
Blood,
May 1, 2007;
109(9):
3989 - 3997.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. S. Nowakowski, J. D. Hoyer, T. D. Shanafelt, S. M. Geyer, B. R. LaPlant, T. G. Call, D. F. Jelinek, C. S. Zent, and N. E. Kay
Using Smudge Cells on Routine Blood Smears to Predict Clinical Outcome in Chronic Lymphocytic Leukemia: A Universally Available Prognostic Test
Mayo Clin. Proc.,
April 1, 2007;
82(4):
449 - 453.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Bomben, M. Dal Bo, D. Capello, D. Benedetti, D. Marconi, A. Zucchetto, F. Forconi, R. Maffei, E. M. Ghia, L. Laurenti, et al.
Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study
Blood,
April 1, 2007;
109(7):
2989 - 2998.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. R. Kolar, D. Mehta, R. Pelayo, and J. D. Capra
A novel human B cell subpopulation representing the initial germinal center population to express AID
Blood,
March 15, 2007;
109(6):
2545 - 2552.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Grever, D. M. Lucas, G. W. Dewald, D. S. Neuberg, J. C. Reed, S. Kitada, I. W. Flinn, M. S. Tallman, F. R. Appelbaum, R. A. Larson, et al.
Comprehensive Assessment of Genetic and Molecular Features Predicting Outcome in Patients With Chronic Lymphocytic Leukemia: Results From the US Intergroup Phase III Trial E2997
J. Clin. Oncol.,
March 1, 2007;
25(7):
799 - 804.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Ocana, L. Delgado-Perez, A. Campos-Caro, J. Munoz, A. Paz, R. Franco, and J. A. Brieva
The prognostic role of CXCR3 expression by chronic lymphocytic leukemia B cells
Haematologica,
March 1, 2007;
92(3):
349 - 356.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gobessi, L. Laurenti, P. G. Longo, S. Sica, G. Leone, and D. G. Efremov
ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells
Blood,
March 1, 2007;
109(5):
2032 - 2039.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. D. Volkheimer, J. B. Weinberg, B. E. Beasley, J. F. Whitesides, J. P. Gockerman, J. O. Moore, G. Kelsoe, B. K. Goodman, and M. C. Levesque
Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification
Blood,
February 15, 2007;
109(4):
1559 - 1567.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Van Bockstaele, V. Pede, A. Janssens, F. Callewaert, F. Offner, B. Verhasselt, and J. Philippe
Lipoprotein Lipase mRNA Expression in Whole Blood Is a Prognostic Marker in B Cell Chronic Lymphocytic Leukemia
Clin. Chem.,
February 1, 2007;
53(2):
204 - 212.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Stamatopoulos, C. Belessi, C. Moreno, M. Boudjograh, G. Guida, T. Smilevska, L. Belhoul, S. Stella, N. Stavroyianni, M. Crespo, et al.
Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations
Blood,
January 1, 2007;
109(1):
259 - 270.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Tinhofer, G. Rubenzer, C. Holler, E. Hofstaetter, M. Stoecher, A. Egle, M. Steurer, and R. Greil
Expression levels of CD38 in T cells predict course of disease in male patients with B-chronic lymphocytic leukemia
Blood,
November 1, 2006;
108(9):
2950 - 2956.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Dicker, S. Schnittger, T. Haferlach, W. Kern, and C. Schoch
Immunostimulatory oligonucleotide-induced metaphase cytogenetics detect chromosomal aberrations in 80% of CLL patients: a study of 132 CLL cases with correlation to FISH, IgVH status, and CD38 expression
Blood,
November 1, 2006;
108(9):
3152 - 3160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. D. Shanafelt, T. E. Witzig, S. R. Fink, R. B. Jenkins, S. F. Paternoster, S. A. Smoley, K. J. Stockero, D. M. Nast, H. C. Flynn, R. C. Tschumper, et al.
Prospective Evaluation of Clonal Evolution During Long-Term Follow-Up of Patients With Untreated Early-Stage Chronic Lymphocytic Leukemia
J. Clin. Oncol.,
October 1, 2006;
24(28):
4634 - 4641.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. H. Frey, H. Nuckel, L. Sellmann, D. Siemer, R. Kuppers, J. Durig, U. Duhrsen, and W. Siffert
The GNAS1 T393C Polymorphism Is Associated with Disease Progression and Survival in Chronic Lymphocytic Leukemia.
Clin. Cancer Res.,
October 1, 2006;
12(19):
5686 - 5692.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. D. Shanafelt, J. C. Byrd, T. G. Call, C. S. Zent, and N. E. Kay
Narrative review: initial management of newly diagnosed, early-stage chronic lymphocytic leukemia.
Ann Intern Med,
September 19, 2006;
145(6):
435 - 447.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. F. Fecteau, G. Cote, and S. Neron
A New Memory CD27-IgG+ B Cell Population in Peripheral Blood Expressing VH Genes with Low Frequency of Somatic Mutation
J. Immunol.,
September 15, 2006;
177(6):
3728 - 3736.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. G. Polson, B. Zheng, K. Elkins, W. Chang, C. Du, P. Dowd, L. Yen, C. Tan, J.-A. Hongo, H. Koeppen, et al.
Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia
Int. Immunol.,
September 1, 2006;
18(9):
1363 - 1373.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
