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Blood, Vol. 94 No. 6 (September 15), 1999:
pp. 2065-2071
Hodgkin/Reed-Sternberg Cells Induce Fibroblasts to Secrete Eotaxin,
a Potent Chemoattractant for T Cells and Eosinophils
Franziska Jundt,
Ioannis Anagnostopoulos,
Kurt Bommert,
Florian Emmerich,
Gerd Müller,
Hans-Dieter Foss,
Hans-Dieter Royer,
Harald Stein, and
Bernd Dörken
From the Universitätsklinikum Charité,
Robert-Rössle-Klinik, Humboldt University of Berlin, Berlin,
Germany; the Max Delbrück Center for Molecular Medicine, Berlin,
Germany; and the Institute of Pathology, Klinikum Benjamin Franklin,
Free University of Berlin, Berlin, Germany.
Hodgkin's disease is histopathologically characterized by the
relative scarcity of neoplastic Hodgkin and Reed-Sternberg cells and
for yet unknown reasons by an abundant reactive background of T
lymphocytes and often eosinophils. Eotaxin is a CC-chemokine attracting
eosinophils and T helper 2 (Th2) cells in allergic inflammation. We now
report that eotaxin is strongly expressed in fibroblasts of Hodgkin's
disease tissues, whereas Hodgkin/Reed-Sternberg cells do not express
this chemokine. In tissue culture, Hodgkin's disease tumor cells
induce eotaxin expression in cocultured dermal fibroblasts in a
concentration leading to a specific chemotactic response of a Th2 cell
clone. Production of tumor necrosis factor- (TNF-) by
Hodgkin/Reed-Sternberg cells appears to be responsible for this
induction, because blocking of TNF- by neutralizing antibodies
prevented fibroblast eotaxin expression. Our data suggest that eotaxin
is involved in the pathobiology of Hodgkin's disease by contributing
to eosinophil and T-lymphocyte recruitment.
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