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Blood, Vol. 94 No. 7 (October 1), 1999:
pp. 2533-2536
TECK, an Efficacious Chemoattractant for Human Thymocytes, Uses
GPR-9-6/CCR9 as a Specific Receptor
Byung-S. Youn,
Chang H. Kim,
Franklin O. Smith, and
Hal E. Broxmeyer
From the Departments of Microbiology/Immunology and Medicine, the
Walther Oncology Center, and the Herman B Wells Center for Pediatric
Research, Indiana University School of Medicine, Indianapolis, IN; and
the Walther Cancer Institute, Indianapolis, IN.
Chemokines regulate leukocytes trafficking in normal and
inflammation conditions. Thymus-seeding progenitors are made in bone marrow and migrate to the thymus where they undergo their maturation to
antigen-specific T cells. Immature T cells are in thymic cortex, while
mature thymocytes are in medulla. Chemokines may be important for
homing of thymus-seeding progenitors, and/or differential thymocyte
localization in thymus. Here we report that GPR-9-6, now called CC
chemokine receptor 9 (CCR9), is a receptor for thymus-expressed chemokine, TECK. Among a panel of chemokines tested, TECK specifically induced calcium flux in CCR9-expressing cell lines. We also showed that
TECK efficaciously induced chemotaxis of immature
CD4+CD8+ double-positive, and mature
CD4+ and CD8+ single-positive human
thymocytes. Our data suggest that TECK/CCR9 interaction may play a
pivotal role in T-cell migration in the thymus.
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