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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Res, P. C.M. Articles by Spits, H. Search for Related Content PubMed PubMed Citation Articles by Res, P. C.M. Articles by Spits, H. Related Collections Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, Vol. 94 No. 8 (October 15), 1999: pp. 2647-2657 Expression of pT mRNA in a Committed Dendritic Cell Precursor in the Human Thymus Pieter C.M. Res, Franka Couwenberg, Florry A. Vyth-Dreese, and Hergen Spits From the Division of Immunology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Amsterdam, The Netherlands. We have characterized dendritic cell precursors (pre-DC) in the human thymus. These CD1aCD3CD4+CD8 cells express high levels of interleukin-3R (IL-3R) on the membrane and are able to develop into mature DC upon culture with IL-3 and CD40 ligation. The DC precursors are predominantly located in the thymic medulla. Interestingly, the pre-DC express pT mRNA, which is also present in CD1a+CD3CD4+ CD8 pre-T cells. Yet, the pre-DC lack expression of recombination activating gene-1 mRNA and fail to develop into T cells in appropriate assays. The thymic pre-DC are very similar to the recently characterized pre-DC found in the T cell areas of the tonsil, and it is suggested that these pre-DC populations are of lymphoid origin. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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