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Blood, Vol. 94 No. 9 (November 1), 1999:
pp. 3161-3168
CD137 Induces Proliferation and Endomitosis in Monocytes
Joachim Langstein,
Jan Michel, and
Herbert Schwarz
From the Department of Pathology, University of Regensburg,
Regensburg, Germany.
Peripheral monocytes are short-lived and are replenished from
hematopoietic stem cells whose proliferation is believed to be confined
to the bone marrow. Human peripheral monocytes are assumed not to be
able to proliferate. In this study we show that CD137 (ILA/4-1BB), a
member of the tumor necrosis factor receptor family, induces a
widespread and profound proliferation of human peripheral monocytes.
Macrophage colony-stimulating factor and granulocyte-macrophage
colony-stimulating factor are essential, but not sufficient for
proliferation. Additional soluble autocrine factors induced by CD137
are required. Induction of proliferation is mediated via reverse
signaling through a CD137 ligand, expressed constitutively by
peripheral monocytes. The ability of CD137 to induce proliferation in
human peripheral monocytes is not shared by any other known molecule.
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