|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 94 No. 9 (November 1), 1999:
pp. 3258-3261
The t(11;20)(p15;q11) Chromosomal Translocation Associated With
Therapy-Related Myelodysplastic Syndrome Results in an
NUP98-TOP1 Fusion
Harish G. Ahuja,
Carolyn A. Felix, and
Peter D. Aplan
From the Departments of Medicine, Pediatrics, and
Cancer Genetics, Roswell Park Cancer Institute,
Buffalo, NY; the Division of Oncology,
The Children's Hospital of Philadelphia, University
of Pennsylvania School of Medicine, Philadelphia, PA; and
the Division of Hematology/Oncology, Children's
Hospital of Buffalo, Buffalo, NY.
The NUP98 gene is involved in 3 distinct chromosomal
rearrangements, t(7;11)(p15;p15), t(2;11)(q31;p15), and
inv(11)(p15q22); all of these NUP98 rearrangements have been
identified in the malignant cells of patients with therapy-related
acute myelogenous leukemia or myelodysplastic syndrome (t-AML/MDS).
Here we report the cloning and characterization of a t(11;20)(p15;q11)
translocation from patients with t-MDS. The breakpoint on chromosome
11p15 targets the NUP98 gene and results in the separation of
the N-terminal FXFG repeats from the RNA-binding domain located in the
C-terminus. The breakpoint on chromosome 20q11 occurs within the gene
encoding human DNA topoisomerase I (TOP1). As a result, a
chimeric mRNA encoding the NUP98 FXFG repeats fused to the body of DNA
topoisomerase I is produced. These results indicate that NUP98
is a recurrent target in therapy-related malignancies, and that
TOP1 is a previously unrecognized target for chromosomal translocations.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
P. Gorello, L. Brandimarte, R. La Starza, V. Pierini, L. Bury, R. Rosati, M. F. Martelli, P. Vandenberghe, I. Wlodarska, and C. Mecucci
t(3;11)(q12;p15)/NUP98-LOC348801 fusion transcript in acute myeloid leukemia
Haematologica,
September 1, 2008;
93(9):
1398 - 1401.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Nebral, H. H. Schmidt, O. A. Haas, and S. Strehl
NUP98 Is Fused to Topoisomerase (DNA) II{beta} 180 kDa (TOP2B) in a Patient with Acute Myeloid Leukemia with a New t(3;11)(p24;p15)
Clin. Cancer Res.,
September 15, 2005;
11(18):
6489 - 6494.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-W. Lin, C. Slape, Z. Zhang, and P. D. Aplan
NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia
Blood,
July 1, 2005;
106(1):
287 - 295.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. Gurevich, P. D. Aplan, and R. K. Humphries
NUP98-Topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation
Blood,
August 15, 2004;
104(4):
1127 - 1136.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Lahortiga, J. L. Vizmanos, X. Agirre, I. Vazquez, J. C. Cigudosa, M. J. Larrayoz, F. Sala, A. Gorosquieta, K. Perez-Equiza, M. J. Calasanz, et al.
NUP98 Is Fused to Adducin 3 in a Patient with T-Cell Acute Lymphoblastic Leukemia and Myeloid Markers, with a New Translocation t(10;11)(q25;p15)
Cancer Res.,
June 15, 2003;
63(12):
3079 - 3083.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Hirai
Molecular Mechanisms of Myelodysplastic Syndrome
Jpn. J. Clin. Oncol.,
April 1, 2003;
33(4):
153 - 160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Taketani, T. Taki, N. Shibuya, A. Kikuchi, R. Hanada, and Y. Hayashi
Novel NUP98-HOXC11 Fusion Gene Resulted from a Chromosomal Break within Exon 1 of HOXC11 in Acute Myeloid Leukemia with t(11;12)(p15;q13)
Cancer Res.,
August 15, 2002;
62(16):
4571 - 4574.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Rosati, R. La Starza, A. Veronese, A. Aventin, C. Schwienbacher, T. Vallespi, M. Negrini, M. F. Martelli, and C. Mecucci
NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15)
Blood,
May 15, 2002;
99(10):
3857 - 3860.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Pedersen-Bjergaard, M. K. Andersen, D. H. Christiansen, and C. Nerlov
Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia
Blood,
March 15, 2002;
99(6):
1909 - 1912.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Fujino, A. Suzuki, Y. Ito, K. Ohyashiki, Y. Hatano, I. Miura, and T. Nakamura
Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15)
Blood,
February 15, 2002;
99(4):
1428 - 1433.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Hussey and A. Dobrovic
Recurrent coiled-coil motifs in NUP98 fusion partners provide a clue to leukemogenesis
Blood,
February 1, 2002;
99(3):
1097 - 1097.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Taketani, T. Taki, N. Shibuya, E. Ito, J. Kitazawa, K. Terui, and Y. Hayashi
The HOXD11 Gene Is Fused to the NUP98 Gene in Acute Myeloid Leukemia with t(2;11)(q31;p15)
Cancer Res.,
January 1, 2002;
62(1):
33 - 37.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Jaju, C. Fidler, O. A. Haas, A. J. Strickson, F. Watkins, K. Clark, N. C. P. Cross, J.-F. Cheng, P. D. Aplan, L. Kearney, et al.
A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia
Blood,
August 15, 2001;
98(4):
1264 - 1267.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. G. Ahuja, J. Hong, P. D. Aplan, L. Tcheurekdjian, S. J. Forman, and M. L. Slovak
t(9;11)(p22;p15) in Acute Myeloid Leukemia Results in a Fusion between NUP98 and the Gene Encoding Transcriptional Coactivators p52 and p75-Lens Epithelium-derived Growth Factor (LEDGF)
Cancer Res.,
November 1, 2000;
60(22):
6227 - 6229.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
B. M. A. Fontoura, G. Blobel, and N. R. Yaseen
The Nucleoporin Nup98 Is a Site for GDP/GTP Exchange on Ran and Termination of Karyopherin beta 2-mediated Nuclear Import
J. Biol. Chem.,
September 29, 2000;
275(40):
31289 - 31296.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
