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Related Collections Immunobiology Review Articles Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, Vol. 95 No. 10 (May 15), 2000: pp. 3032-3043 REVIEW ARTICLE Chemokine receptors and their role in inflammation and infectious diseases Craig Murdoch and Adam Finn From the Division of Child Health, University of Sheffield, Sheffield Children's Hospital, Sheffield, United Kingdom. Chemokines are small peptides that are potent activators and chemoattractants for leukocyte subpopulations and some nonhemopoietic cells. Their actions are mediated by a family of 7-transmembrane G-protein-coupled receptors, the size of which has grown considerably in recent years and now includes 18 members. Chemokine receptor expression on different cell types and their binding and response to specific chemokines are highly variable. Significant advances have been made in understanding the regulation of chemokine receptor expression and the intracellular signaling mechanisms used in bringing about cell activation. Chemokine receptors have also recently been implicated in several disease states including allergy, psoriasis, atherosclerosis, and malaria. However, most fascinating has been the observation that some of these receptors are used by human immunodeficiency virus type 1 in gaining entry into permissive cells. This review will discuss structural and functional aspects of chemokine receptor biology and will consider the roles these receptors play in inflammation and in infectious diseases. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Prat, P.-J. Haas, J. Bestebroer, C. J. C. de Haas, J. A. G. van Strijp, and K. P. 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Schols Mutation of Asp171 and Asp262 of the Chemokine Receptor CXCR4 Impairs Its Coreceptor Function for Human Immunodeficiency Virus-1 Entry and Abrogates the Antagonistic Activity of AMD3100 Mol. Pharmacol., July 1, 2001; 60(1): 164 - 173. [Abstract] [Full Text] S. Yousefi, P. R Cooper, S. L Potter, B. Mueck, and G. Jarai Cloning and expression analysis of a novel G-protein-coupled receptor selectively expressed on granulocytes J. Leukoc. Biol., June 1, 2001; 69(6): 1045 - 1052. [Abstract] [Full Text] [PDF] M. C Cook Immunology of trauma Trauma, April 1, 2001; 3(2): 79 - 88. [Abstract] [PDF] R. Gillitzer and M. Goebeler Chemokines in cutaneous wound healing J. Leukoc. Biol., April 1, 2001; 69(4): 513 - 521. [Abstract] [Full Text] R. D. M. Soede, I. S. Zeelenberg, Y. M. Wijnands, M. Kamp, and E. Roos Stromal Cell-Derived Factor-1-Induced LFA-1 Activation During In Vivo Migration of T Cell Hybridoma Cells Requires Gq/11, RhoA, and Myosin, as well as Gi and Cdc42 J. Immunol., April 1, 2001; 166(7): 4293 - 4301. [Abstract] [Full Text] [PDF] B. A. Garvy and M. H. Qureshi Delayed Inflammatory Response to Pneumocystis carinii Infection in Neonatal Mice Is Due to an Inadequate Lung Environment J. Immunol., December 1, 2000; 165(11): 6480 - 6486. [Abstract] [Full Text] [PDF] M. R. Mayer and M. J. Stone Identification of Receptor Binding and Activation Determinants in the N-terminal and N-loop Regions of the CC Chemokine Eotaxin J. Biol. Chem., April 20, 2001; 276(17): 13911 - 13916. [Abstract] [Full Text] [PDF] L. S. Mizoue, S. K. Sullivan, D. S. King, T. N. Kledal, T. W. Schwartz, K. B. Bacon, and T. M. Handel Molecular Determinants of Receptor Binding and Signaling by the CX3C Chemokine Fractalkine J. Biol. Chem., August 31, 2001; 276(36): 33906 - 33914. [Abstract] [Full Text] [PDF] D. E. Wright, E. P. Bowman, A. J. Wagers, E. C. Butcher, and I. L. Weissman Hematopoietic Stem Cells Are Uniquely Selective in Their Migratory Response to Chemokines J. Exp. Med., May 6, 2002; 195(9): 1145 - 1154. [Abstract] [Full Text] [PDF] J. E. Feugate, Q. Li, L. Wong, and M. Martins-Green The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure J. Cell Biol., January 7, 2002; 156(1): 161 - 172. [Abstract] [Full Text] [PDF]

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