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Blood, Vol. 95 No. 10 (May 15), 2000:
pp. 3052-3056
Rituximab monoclonal antibody as initial systemic therapy for
patients with low-grade non-Hodgkin lymphoma
John D. Hainsworth,
Howard A. Burris III,
Lisa H. Morrissey,
Sharlene Litchy,
Daniel C. Scullin Jr,
James D. Bearden III,
Paul Richards, and
F. Anthony Greco
From the Sarah Cannon Cancer Center, Centennial Medical Center,
Nashville, TN; Tennessee Oncology PLLC, Nashville, TN; Consultants in
Blood Disorders and Cancer, Louisville, KY; Upstate Carolina, CCOP,
Spartanburg, SC; Oncology and Hematology Associates of Southwest
Virginia, Inc, Roanoke, VA.
Rituximab, a chimeric antibody that targets CD20+ B
cells, produces a 48% response rate in patients with refractory
low-grade non-Hodgkin lymphoma. In this phase II trial, patients with
low-grade non-Hodgkin lymphoma who had previously received no systemic
therapy were treated with rituximab, 375 mg/m2,
administered by IV infusion for 4 consecutive weeks. Patients with
objective response or stable disease received repeat 4-week courses of
rituximab at 6-month intervals. At the time of initial reevaluation at
6 weeks, 21 of 39 patients (54%) had objective response to treatment,
and an additional 14 patients (36%) had stable disease or minor
response. Response rates were similar in patients with follicular and
small lymphocytic (CLL-type) lymphoma (52% versus 57%, respectively).
At present, follow-up is short and only 13 patients have undergone a
second course of rituximab treatment. However, 4 additional responses
were documented either prior to the second course of rituximab (2 patients) or following the second course (2 patients) and 4 patients
improved from partial to complete response. The current response rate
is 64%, with 6 complete responses (15%). Treatment with rituximab was
well tolerated, with only 1 patient experiencing grade 3/4
infusion-related toxicity. Rituximab is well tolerated and highly
active in patients with low-grade non-Hodgkin lymphoma previously
untreated with systemic therapy. Although further follow-up is
required, the demonstration of minimal toxicity and considerable
activity of this new biologic agent represents an important beginning
of more specific, less toxic treatment for this important group of
cancer patients.
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I. F. Khouri, R. M. Saliba, C. Hosing, G.-J. Okoroji, S. Acholonu, P. Anderlini, D. Couriel, M. De Lima, M. L. Donato, L. Fayad, et al.
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|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
|
J. A Krieger, J. M Merin, and I. Rabinowitz
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8(4):
127 - 129.
[Abstract]
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|
|
|
|
|
|
|
J. D. Hainsworth, S. Litchy, H. A. Burris III, D. C. Scullin Jr, S. W. Corso, D. A. Yardley, L. Morrissey, and F. A. Greco
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20(20):
4261 - 4267.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. O. Dillman
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20(16):
3545 - 3557.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Dimopoulos, C. Zervas, A. Zomas, C. Kiamouris, N. A. Viniou, V. Grigoraki, C. Karkantaris, C. Mitsouli, D. Gika, J. Christakis, et al.
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20(9):
2327 - 2333.
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[Full Text]
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|
|
|
|
|
|
|
T. Decker, S. Hipp, R. J. Kreitman, I. Pastan, C. Peschel, and T. Licht
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99(4):
1320 - 1326.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
G. Cartron, L. Dacheux, G. Salles, P. Solal-Celigny, P. Bardos, P. Colombat, and H. Watier
Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor Fcgamma RIIIa gene
Blood,
February 1, 2002;
99(3):
754 - 758.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Ansell, T. E. Witzig, P. J. Kurtin, J. A. Sloan, D. F. Jelinek, K. G. Howell, S. N. Markovic, T. M. Habermann, G. G. Klee, P. J. Atherton, et al.
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January 1, 2002;
99(1):
67 - 74.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Bellosillo, N. Villamor, A. Lopez-Guillermo, S. Marce, J. Esteve, E. Campo, D. Colomer, and E. Montserrat
Complement-mediated cell death induced by rituximab in B-cell lymphoproliferative disorders is mediated in vitro by a caspase-independent mechanism involving the generation of reactive oxygen species
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November 1, 2001;
98(9):
2771 - 2777.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. D. Cheson
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19(19):
3908 - 3911.
[Full Text]
|
|
|
|
|
|
|
D. Huhn, C. von Schilling, M. Wilhelm, A. D. Ho, M. Hallek, R. Kuse, W. Knauf, U. Riedel, A. Hinke, S. Srock, et al.
Rituximab therapy of patients with B-cell chronic lymphocytic leukemia
Blood,
September 1, 2001;
98(5):
1326 - 1331.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. E. Schnipper and T. B. Strom
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July 26, 2001;
345(4):
283 - 284.
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Dubey, H. Wu, R. E. Reiter, and O. N. Witte
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Cancer Res.,
April 1, 2001;
61(8):
3256 - 3261.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
O. W. Press, J. P. Leonard, B. Coiffier, R. Levy, and J. Timmerman
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Hematology,
January 1, 2001;
2001(1):
221 - 240.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Colombat, G. Salles, N. Brousse, P. Eftekhari, P. Soubeyran, V. Delwail, E. Deconinck, C. Haioun, C. Foussard, C. Sebban, et al.
Rituximab (anti-CD20 monoclonal antibody) as single first-line therapy for patients with follicular lymphoma with a low tumor burden: clinical and molecular evaluation
Blood,
January 1, 2001;
97(1):
101 - 106.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Hainsworth
Monoclonal Antibody Therapy in Lymphoid Malignancies
Oncologist,
October 1, 2000;
5(5):
376 - 384.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. A. Waldmann, R. Levy, and B. S. Coller
Emerging Therapies: Spectrum of Applications of Monoclonal Antibody Therapy
Hematology,
January 1, 2000;
2000(1):
394 - 408.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
