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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gehling, U. M. Articles by Fiedler, W. Search for Related Content PubMed PubMed Citation Articles by Gehling, U. M. Articles by Fiedler, W. Related Collections Hematopoiesis and Stem Cells Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, Vol. 95 No. 10 (May 15), 2000: pp. 3106-3112 In vitro differentiation of endothelial cells from AC133-positive progenitor cells Ursula M. Gehling, Süleyman Ergün, Udo Schumacher, Christoph Wagener, Klaus Pantel, Marcus Otte, Gunter Schuch, Philippe Schafhausen, Thorsten Mende, Nerbil Kilic, Katrin Kluge, Birgit Schäfer, Dieter K. Hossfeld, and Walter Fiedler From the Department of Hematology/Oncology, Department of Anatomy, Department of Neuroanatomy, Department of Clinical Chemistry, and Department of Gynecology, University Hospital Eppendorf, Hamburg, Germany. Recent findings support the hypothesis that the CD34+-cell population in bone marrow and peripheral blood contains hematopoietic and endothelial progenitor and stem cells. In this study, we report that human AC133+ cells from granulocyte colony-stimulating factor-mobilized peripheral blood have the capacity to differentiate into endothelial cells (ECs). When cultured in the presence of vascular endothelial growth factor (VEGF) and the novel cytokine stem cell growth factor (SCGF), AC133+ progenitors generate both adherent and proliferating nonadherent cells. Phenotypic analysis of the cells within the adherent population reveals that the majority display endothelial features, including the expression of KDR, Tie-2, Ulex europaeus agglutinin-1, and von Willebrand factor. Electron microscopic studies of these cells show structures compatible with Weibel-Palade bodies that are found exclusively in vascular endothelium. AC133-derived nonadherent cells give rise to both hematopoietic and endothelial colonies in semisolid medium. On transfer to fresh liquid culture with VEGF and SCGF, nonadherent cells again produce an adherent and a nonadherent population. In mice with severe combined immunodeficiency, AC133-derived cells form new blood vessels in vivo when injected subcutaneously together with A549 lung cancer cells. These data indicate that the AC133+-cell population consists of progenitor and stem cells not only with hematopoietic potential but also with the capacity to differentiate into ECs. Whether these hematopoietic and endothelial progenitors develop from a common precursor, the hemangioblast will be studied at the single-cell level. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Madonna, Y.-J. Geng, and R. De Caterina Adipose Tissue-Derived Stem Cells: Characterization and Potential for Cardiovascular Repair Arterioscler Thromb Vasc Biol, November 1, 2009; 29(11): 1723 - 1729. [Abstract] [Full Text] [PDF] M. Ii, H. Nishimura, H. Sekiguchi, N. Kamei, A. Yokoyama, M. Horii, and T. Asahara Concurrent Vasculogenesis and Neurogenesis From Adult Neural Stem Cells Circ. Res., October 23, 2009; 105(9): 860 - 868. [Abstract] [Full Text] [PDF] M. Toshner, R. Voswinckel, M. Southwood, R. Al-Lamki, L. S. G. Howard, D. Marchesan, J. Yang, J. Suntharalingam, E. Soon, A. Exley, et al. Evidence of Dysfunction of Endothelial Progenitors in Pulmonary Arterial Hypertension Am. J. Respir. Crit. 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