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Related Collections Hematopoiesis and Stem Cells Cell Adhesion and Motility Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, Vol. 95 No. 11 (June 1), 2000: pp. 3289-3296 The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34+ cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice Amnon Peled, Orit Kollet, Tanya Ponomaryov, Isabelle Petit, Suzanna Franitza, Valentin Grabovsky, Michal Magid Slav, Arnon Nagler, Ofer Lider, Ronen Alon, Dov Zipori, and Tsvee Lapidot From the Departments of Immunology and Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel, and the Haddasa University Hospital, Jerusalem, Israel. Hematopoietic stem cell homing and engraftment require several adhesion interactions, which are not fully understood. Engraftment of nonobese/severe combined immunodeficiency (NOD/SCID) mice by human stem cells is dependent on the major integrins very late activation antigen-4 (VLA-4); VLA-5; and to a lesser degree, lymphocyte function associated antigen-1 (LFA-1). Treatment of human CD34+ cells with antibodies to either VLA-4 or VLA-5 prevented engraftment, and treatment with anti-LFA-1 antibodies significantly reduced the levels of engraftment. Activation of CD34+ cells, which bear the chemokine receptor CXCR4, with stromal derived factor 1 (SDF-1) led to firm adhesion and transendothelial migration, which was dependent on LFA-1/ICAM-1 (intracellular adhesion molecule-1) and VLA-4/VCAM-1 (vascular adhesion molecule-1). Furthermore, SDF-1-induced polarization and extravasation of CD34+/CXCR4+ cells through the extracellular matrix underlining the endothelium was dependent on both VLA-4 and VLA-5. Our results demonstrate that repopulating human stem cells functionally express LFA-1, VLA-4, and VLA-5. 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Nagler, and T. Lapidot Rapid and efficient homing of human CD34+CD38{-}/lowCXCR4+ stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2mnull mice Blood, May 15, 2001; 97(10): 3283 - 3291. [Abstract] [Full Text] [PDF] D. E. Wright, E. P. Bowman, A. J. Wagers, E. C. Butcher, and I. L. Weissman Hematopoietic Stem Cells Are Uniquely Selective in Their Migratory Response to Chemokines J. Exp. Med., May 6, 2002; 195(9): 1145 - 1154. [Abstract] [Full Text] [PDF]

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