|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 95 No. 11 (June 1), 2000:
pp. 3473-3477
Acquisition of intact allogeneic human leukocyte antigen
molecules by human dendritic cells
Vincenzo Russo,
Dan Zhou,
Claudia Sartirana,
Patrizia Rovere,
Antonello Villa,
Silvano Rossini,
Catia Traversari, and
Claudio Bordignon
From the HSR-Telethon Institute of Gene Therapy
(TIGET) and the Cancer Immunotherapy and Gene Therapy Program, H.S.
Raffaele Scientific Institute, Milan, Italy, and the Microscopy and
Image Analysis, HSR, and Faculty of Medicine, the University of Milan
Bicocca, Milan, Italy, and Gen Era S.P.A.
In an attempt to transduce monocyte-derived dendritic cells (DCs) by
a retroviral vector coding for a cell surface marker, we were
confronted by the observation of high transfer of the surface molecule
in the absence of vector proviral DNA in the treated cells. Indeed, DCs
acquired the surface marker by a mechanism independent of the vector
machinery, requiring cell-to-cell contact and involving transfer of
lipids and a variety of intact membrane proteins. Most important, this
property of DCs also includes acquisition of foreign human leukocyte
antigen (HLA) molecules. Consequently, DCs become immunological hybrids
as they display their own and foreign HLA molecules. The newly acquired
HLA is fully functional because it allows recognition by allo-specific
T lymphocytes and the binding and presentation of antigen peptides.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. Hudrisier, B. Clemenceau, S. Balor, S. Daubeuf, E. Magdeleine, M. Daeron, P. Bruhns, and H. Vie
Ligand Binding but Undetected Functional Response of FcR after Their Capture by T Cells via Trogocytosis
J. Immunol.,
November 15, 2009;
183(10):
6102 - 6113.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kuipers, T. Soullie, H. Hammad, M. Willart, M. Kool, D. Hijdra, H. C. Hoogsteden, and B. N. Lambrecht
Sensitization by intratracheally injected dendritic cells is independent of antigen presentation by host antigen-presenting cells
J. Leukoc. Biol.,
January 1, 2009;
85(1):
64 - 70.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Brown, S. H. Sacks, and W. Wong
Extensive and bidirectional transfer of major histocompatibility complex class II molecules between donor and recipient cells in vivo following solid organ transplantation
FASEB J,
November 1, 2008;
22(11):
3776 - 3784.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. P. Dolan, K. D. Gibbs Jr., and S. Ostrand-Rosenberg
Tumor-Specific CD4+ T Cells Are Activated by "Cross-Dressed" Dendritic Cells Presenting Peptide-MHC Class II Complexes Acquired from Cell-Based Cancer Vaccines
J. Immunol.,
February 1, 2006;
176(3):
1447 - 1455.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Vanherberghen, K. Andersson, L. M. Carlin, E. N. M. Nolte-`t Hoen, G. S. Williams, P. Hoglund, and D. M. Davis
Human and murine inhibitory natural killer cell receptors transfer from natural killer cells to target cells
PNAS,
November 30, 2004;
101(48):
16873 - 16878.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Morelli, A. T. Larregina, W. J. Shufesky, M. L. G. Sullivan, D. B. Stolz, G. D. Papworth, A. F. Zahorchak, A. J. Logar, Z. Wang, S. C. Watkins, et al.
Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells
Blood,
November 15, 2004;
104(10):
3257 - 3266.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. B. Herrera, D. Golshayan, R. Tibbott, F. S. Ochoa, M. J. James, F. M. Marelli-Berg, and R. I. Lechler
A Novel Pathway of Alloantigen Presentation by Dendritic Cells
J. Immunol.,
October 15, 2004;
173(8):
4828 - 4837.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Ferlazzo, C. Semino, G. M. Spaggiari, M. Meta, M. C. Mingari, and G. Melioli
Dendritic cells efficiently cross-prime HLA class I-restricted cytolytic T lymphocytes when pulsed with both apoptotic and necrotic cells but not with soluble cell-derived lysates
Int. Immunol.,
December 1, 2000;
12(12):
1741 - 1747.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
