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Blood, Vol. 95 No. 11 (June 1), 2000:
pp. 3530-3533
Expression of gene MAGE-A4 in Reed-Sternberg cells
Hervé Chambost,
Nicolas Van Baren,
Francis Brasseur,
Danièle Godelaine,
Luc Xerri,
Sylvaine Just Landi,
Ivan Theate,
Joel Plumas,
Guilio C. Spagnoli,
Gerard Michel,
Pierre G. Coulie, and
Daniel Olive
From INSERM U119 and Unité d'Immunologie des Tumeurs,
Institut Paoli Calmettes, Marseilles, France; the Ludwig Institute for
Cancer Research, Brussels, Belgium; Unité de
Génétique Cellulaire, Université catholique de
Louvain, Brussels, Belgium; Service d'Anatomopathologie, Institut
Paoli Calmettes, Marseilles, France; Service d'Anatomopathologie,
Cliniques Universitaires Saint-Luc, Brussels, Belgium; ETS
Isère-Savoie and Research Group on Lymphoma, Unité UPRES
2021, Grenoble, France; the Department of Surgery, Research Division,
University of Basel, Switzerland; and Service de Pédiatrie et
d'Hématologie Pédiatrique, CHU Timone, Marseilles,
France.
Genes of the MAGE-A family are expressed in several
types of solid tumors but are silent in normal tissues with the
exception of male germline cells, which do not carry HLA
molecules.Therefore, peptides encoded by MAGE-A genes are
strictly tumor-specific antigens that can be recognized by CTL and
constitute promising targets for immunotherapy. The expression of 6 genes of the MAGE-A family was tested with reverse
transcriptase-polymerase chain reaction in lymphoma samples.
Among 38 samples of non-Hodgkin lymphoma, 1 anaplastic large
cell lymphoma expressed genes MAGE-A1, -A2, -A3, -A4, and
-A12, and 1 lymphoepithelioid T-cell lymphoma expressed gene
MAGE-A4. Five of 18 samples (28%) from patients with Hodgkin disease expressed gene MAGE-A4. In tissue sections, staining by a monoclonal antibody that recognizes the MAGE-A4 protein was observed in 11 of 53 samples (21%) from patients with Hodgkin disease.
In the positive samples, the Reed-Sternberg cells were strongly stained
whereas the surrounding cells were not. These results indicate that
Hodgkin disease may be a target for specific immunotherapy involving
MAGE-A4 antigens.
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