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Blood, Vol. 95 No. 12 (June 15), 2000:
pp. 3878-3884
Salivary gland mucosa-associated lymphoid tissue lymphoma
immunoglobulin VH genes show frequent use
of V1-69 with distinctive CDR3 features
John A. Miklos,
Steven H. Swerdlow, and
David W. Bahler
From the Department of Pathology, University of Pittsburgh,
Pittsburgh, PA.
Salivary gland mucosa associated lymphoid tissue (MALT)
type lymphomas are B-cell neoplasms that develop out of a reactive infiltrate, often associated with Sjögren's syndrome. Previous reports from our laboratory involving 10 patients suggested these lymphomas expressed a restricted immunoglobulin (Ig)
VH gene repertoire with over use of
V1-69 gene segments. To better determine the frequency of
V1-69 use and whether there may also be selection for CDR3
structures, we sequenced the VH genes from
15 additional cases. Over half of the potentially functional VH genes (8 of 14) used a
VH1 family V1-69 gene
segment, whereas the other cases used different gene segments from the VH1 (V1-46),
VH3 (V3-7, V3-11, V3-30.3,
V3-30.5), and VH4
(V4-39) families. The 8 V1-69 VH
genes used 5 different D segments in various reading frames, but all
used a J4 joining segment. The V1-69 CDR3s showed remarkable
similarities in lengths (12-14 amino acids) and stretches of 2 to 3 amino acids between the V-D and D-J junctions. They did not resemble
CDR3s typical of V1-69 chronic lymphocytic leukemias. This
study extends our earlier work in establishing that salivary gland MALT
lymphomas represent a highly selected B-cell population. Frequent use
of V1-69 appears to differ from MALT lymphomas that develop at
other sites. The high degree of CDR3 similarity among the V1-69
cases suggests that different salivary gland lymphomas may bind
similar, if not identical epitopes. Although the antigen specificities
are presently unknown, similar characteristic CDR3 sequences are often
seen with V1-69 encoded antibodies that have anti-IgG or
rheumatoid factor activity.
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