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Blood, Vol. 95 No. 2 (January 15), 2000:
pp. 627-632
The chemokine receptor CXCR3 is expressed in a subset of B-cell
lymphomas and is a marker of B-cell chronic lymphocytic leukemia
Dan Jones,
Richard J. Benjamin,
Aliakbar Shahsafaei, and
David M. Dorfman
From the Department of Pathology, Brigham and Women's Hospital,
Boston, Massachusetts.
Chemotaxis in leukocytes is mediated through binding of soluble
chemokines to transmembrane G-protein coupled receptors. The chemokine
receptor CXCR3 has been previously shown to be widely expressed on
activated T cells and to mediate T-cell chemotaxis on binding to
various ligands, including Mig, IP-10, and ITAC. By using
immunohistochemical and flow cytometric analysis, we report that CXCR3
is also expressed on a subset of peripheral blood B cells and in
distinct subtypes of B-cell lymphoma. CXCR3 immunohistochemical or flow
cytometric expression was seen in 37 of 39 cases of chronic lymphocytic
leukemia/small lymphocytic lymphoma (diffusely positive in 33 cases),
whereas mantle cell lymphoma (30 cases), follicular lymphoma (27 cases), and small noncleaved cell lymphoma (8 cases) were negative in
all but 2 cases. Strong CXCR3 expression was also seen in splenic
marginal zone lymphoma (14 of 14 cases) and in the monocytoid and
plasmacytic cells in extranodal marginal zone lymphoma (15 of 16 cases). This differential expression of CXCR3 in B-cell tumors
contrasts with that of another B-cell-associated chemokine receptor,
BLR1/CXCR5, which we show here is expressed on all types of B-cell
lymphoma tested. We also report that the CXCR3 ligand, Mig, is
coexpressed on tumor cells in many cases of CLL/SLL (10 of 13 cases
examined) with Mig expression less frequently seen in other B-cell
lymphoma subtypes. Coexpression of CXCR3 and its ligand, Mig, may be an important functional interaction in B-CLL, as well as a useful diagnostic marker for the differential diagnosis of small cell lymphomas.
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