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Blood, Vol. 95 No. 3 (February 1), 2000:
pp. 1100-1105
DFFRY codes for a new human male-specific minor
transplantation antigen involved in bone marrow graft rejection
M. H. J. Vogt,
R. A. de Paus,
P. J. Voogt,
R. Willemze, and
J. H. F. Falkenburg
From the Laboratory of Experimental Hematology, Department of
Hematology, Leiden University Medical Center, Leiden, The Netherlands.
Graft rejection after histocompatibility locus antigen
(HLA)-identical stem cell transplantation results from the recognition of minor histocompatibility antigens on donor stem cells by
immunocompetent T lymphocytes of recipient origin. T-lymphocyte clones
that specifically recognize H-Y epitopes on male target cells have been
generated during graft rejection after sex-mismatched transplantation.
Previously, 2 human H-Y epitopes derived from the same SMCY gene have
been identified that were involved in bone marrow graft rejection. We
report the identification of a new male-specific transplantation antigen encoded by the Y-chromosome-specific gene DFFRY. The
DFFRY-derived peptide was recognized by an HLA-A1 restricted CTL clone,
generated during graft rejection from a female patient with acute
myeloid leukemia who rejected HLA-phenotypically identical bone marrow from her father. The identification of this gene demonstrates that at
least 2 genes present on the human Y-chromosome code for male-specific
transplantation antigens.
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