|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 95 No. 3 (February 1), 2000:
pp. 930-935
Cellular origin and procoagulant properties of microparticles
in meningococcal sepsis
Rienk Nieuwland,
René J. Berckmans,
Sarah McGregor,
Anita N. Böing,
Fred P. H. Th. M. Romijn,
Rudi G. J. Westendorp,
C. Erik Hack, and
Augueste Sturk
From the Departments of Clinical Chemistry, General Internal
Medicine, and Clinical Epidemiology, Leiden University Medical Center,
Leiden, The Netherlands; Department of Physiology, University of
Edinburgh, Edinburgh, United Kingdom; University Hospital Vrije
Universiteit, Amsterdam; and CLB, Sanquin Blood Supply Foundation,
Amsterdam, The Netherlands.
Patients with meningococcal sepsis generally suffer from
disseminated intravascular coagulation (DIC). The aim of this study was
to address whether these patients have elevated numbers of circulating
microparticles that contribute to the development of DIC. Plasma
samples from 5 survivors, 2 nonsurvivors, and 5 healthy volunteers were
analyzed for the presence of microparticles by flow cytometry.
Ongoing coagulation activation in vivo was quantified by enzyme-linked
immunosorbent assay of plasma prothrombin fragment
F1 + 2, and procoagulant properties of microparticles
in vitro were estimated by thrombin-generation assay. On admission, all
patients had increased numbers of microparticles originating from
platelets or granulocytes when compared with controls
(P = .004 and P = .008, respectively). Patients
had elevated levels of F1 + 2 (P = .004),
and their microparticles supported thrombin generation more strongly in
vitro (P = .003) than those of controls. Plasma from
the patient with the most fulminant disease course and severe DIC
contained microparticles that expressed both CD14 and tissue factor,
and these microparticles demonstrated extreme thrombin generation in
vitro. We conclude that patients with meningococcal sepsis have
elevated numbers of circulating microparticles that are procoagulant.
These findings may suggest a novel therapeutic approach to combat
clinical conditions with excessive coagulation activation.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
E. J. van Beers, M. C.L. Schaap, R. J. Berckmans, R. Nieuwland, A. Sturk, F. F. van Doormaal, J. C.M. Meijers, B. J. Biemond, and on behalf of the CURAMA study group*
Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease
Haematologica,
November 1, 2009;
94(11):
1513 - 1519.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Vedder, E. Biro, J. M. F. G. Aerts, R. Nieuwland, G. Sturk, and C. E. M. Hollak
Plasma markers of coagulation and endothelial activation in Fabry disease: impact of renal impairment
Nephrol. Dial. Transplant.,
October 1, 2009;
24(10):
3074 - 3081.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Trappenburg, M. van Schilfgaarde, M. Marchetti, H. M. Spronk, H. t. Cate, A. Leyte, W. E. Terpstra, and A. Falanga
Elevated procoagulant microparticles expressing endothelial and platelet markers in essential thrombocythemia
Haematologica,
July 1, 2009;
94(7):
911 - 918.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Morel, F. Toti, N. Morel, and J.-M. Freyssinet
Microparticles in endothelial cell and vascular homeostasis: are they really noxious?
Haematologica,
March 1, 2009;
94(3):
313 - 317.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Wang, C. Miller, R. F. Swarthout, M. Rao, N. Mackman, and M. B. Taubman
Vascular smooth muscle-derived tissue factor is critical for arterial thrombosis after ferric chloride-induced injury
Blood,
January 15, 2009;
113(3):
705 - 713.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. A. Mostefai, F. Meziani, M. L. Mastronardi, A. Agouni, C. Heymes, C. Sargentini, P. Asfar, M. C. Martinez, and R. Andriantsitohaina
Circulating Microparticles from Patients with Septic Shock Exert Protective Role in Vascular Function
Am. J. Respir. Crit. Care Med.,
December 1, 2008;
178(11):
1148 - 1155.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Agouni, A. H. Lagrue-Lak-Hal, P. H. Ducluzeau, H. A. Mostefai, C. Draunet-Busson, G. Leftheriotis, C. Heymes, M. C. Martinez, and R. Andriantsitohaina
Endothelial Dysfunction Caused by Circulating Microparticles from Patients with Metabolic Syndrome
Am. J. Pathol.,
October 1, 2008;
173(4):
1210 - 1219.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bouchama, C. Kunzelmann, M. Dehbi, A. Kwaasi, A. Eldali, F. Zobairi, J.-M. Freyssinet, and D. de Prost
Recombinant Activated Protein C Attenuates Endothelial Injury and Inhibits Procoagulant Microparticles Release in Baboon Heatstroke
Arterioscler Thromb Vasc Biol,
July 1, 2008;
28(7):
1318 - 1325.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. D. Turco, G. Basta, G. Lazzerini, M. Evangelista, G. Rainaldi, P. Tanganelli, J. H. Christensen, E. B. Schmidt, and R. De Caterina
Effect of the administration of n-3 polyunsaturated fatty acids on circulating levels of microparticles in patients with a previous myocardial infarction
Haematologica,
June 1, 2008;
93(6):
892 - 899.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Scanu, N. Molnarfi, K. J. Brandt, L. Gruaz, J.-M. Dayer, and D. Burger
Stimulated T cells generate microparticles, which mimic cellular contact activation of human monocytes: differential regulation of pro- and anti-inflammatory cytokine production by high-density lipoproteins
J. Leukoc. Biol.,
April 1, 2008;
83(4):
921 - 927.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Schouten, W. J. Wiersinga, M. Levi, and T. van der Poll
Inflammation, endothelium, and coagulation in sepsis
J. Leukoc. Biol.,
March 1, 2008;
83(3):
536 - 545.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-F. Penet, M. Abou-Hamdan, N. Coltel, E. Cornille, G. E. Grau, M. de Reggi, and B. Gharib
Protection against cerebral malaria by the low-molecular-weight thiol pantethine
PNAS,
January 29, 2008;
105(4):
1321 - 1326.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Mackman, R. E. Tilley, and N. S. Key
Role of the Extrinsic Pathway of Blood Coagulation in Hemostasis and Thrombosis
Arterioscler Thromb Vasc Biol,
August 1, 2007;
27(8):
1687 - 1693.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. van den Goor, R. Nieuwland, P. M. Rutten, J. G. Tijssen, C. Hau, A. Sturk, L. Eijsman, and B. A. de Mol
Retransfusion of pericardial blood does not trigger systemic coagulation during cardiopulmonary bypass
Eur. J. Cardiothorac. Surg.,
June 1, 2007;
31(6):
1029 - 1036.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Valera, A. G. Vigo, S. Alonso, L. Barbolla, M. S. Crespo, and N. Fernandez
Peptidoglycan and mannose-based molecular patterns trigger the arachidonic acid cascade in human polymorphonuclear leukocytes
J. Leukoc. Biol.,
April 1, 2007;
81(4):
925 - 933.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Martinez, F. Larbret, F. Zobairi, J. Coulombe, N. Debili, W. Vainchenker, M. Ruat, and J.-M. Freyssinet
Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens
Blood,
November 1, 2006;
108(9):
3012 - 3020.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Boulanger, N. Amabile, and A. Tedgui
Circulating Microparticles: A Potential Prognostic Marker for Atherosclerotic Vascular Disease
Hypertension,
August 1, 2006;
48(2):
180 - 186.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. W. Stief
Thrombin Generation by Exposure of Blood to Endotoxin: A Simple Model to Study Disseminated Intravascular Coagulation
Clinical and Applied Thrombosis/Hemostasis,
April 1, 2006;
12(2):
137 - 161.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. M. van der Zee, E. Biro, Y. Ko, R. J. de Winter, C. E. Hack, A. Sturk, and R. Nieuwland
P-Selectin- and CD63-Exposing Platelet Microparticles Reflect Platelet Activation in Peripheral Arterial Disease and Myocardial Infarction
Clin. Chem.,
April 1, 2006;
52(4):
657 - 664.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Tesse, M. C. Martinez, B. Hugel, K. Chalupsky, C. D. Muller, F. Meziani, D. Mitolo-Chieppa, J.-M. Freyssinet, and R. Andriantsitohaina
Upregulation of Proinflammatory Proteins Through NF-{kappa}B Pathway by Shed Membrane Microparticles Results in Vascular Hyporeactivity
Arterioscler Thromb Vasc Biol,
December 1, 2005;
25(12):
2522 - 2527.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Zeerleder, C. E. Hack, and W. A. Wuillemin
Disseminated Intravascular Coagulation in Sepsis
Chest,
October 1, 2005;
128(4):
2864 - 2875.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Hattori, M. M.H. Khan, R. W. Colman, and L. H. Edmunds Jr
Plasma Tissue Factor Plus Activated Peripheral Mononuclear Cells Activate Factors VII and X in Cardiac Surgical Wounds
J. Am. Coll. Cardiol.,
August 16, 2005;
46(4):
707 - 713.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Perez-Casal, C. Downey, K. Fukudome, G. Marx, and C. H. Toh
Activated protein C induces the release of microparticle-associated endothelial protein C receptor
Blood,
February 15, 2005;
105(4):
1515 - 1522.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Yu, L. May, V. Lhotak, S. Shahrzad, S. Shirasawa, J. I. Weitz, B. L. Coomber, N. Mackman, and J. W. Rak
Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis
Blood,
February 15, 2005;
105(4):
1734 - 1741.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Combes, N. Coltel, M. Alibert, M. van Eck, C. Raymond, I. Juhan-Vague, G. E. Grau, and G. Chimini
ABCA1 Gene Deletion Protects against Cerebral Malaria: Potential Pathogenic Role of Microparticles in Neuropathology
Am. J. Pathol.,
January 1, 2005;
166(1):
295 - 302.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Day, J. L. Reeve, B. Pedersen, D. M Farris, D. D. Myers, M. Im, T. W. Wakefield, N. Mackman, and W. P. Fay
Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall
Blood,
January 1, 2005;
105(1):
192 - 198.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Gasser and J. A. Schifferli
Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis
Blood,
October 15, 2004;
104(8):
2543 - 2548.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Aras, A. Shet, R. R. Bach, J. L. Hysjulien, A. Slungaard, R. P. Hebbel, G. Escolar, B. Jilma, and N. S. Key
Induction of microparticle- and cell-associated intravascular tissue factor in human endotoxemia
Blood,
June 15, 2004;
103(12):
4545 - 4553.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Mackman
Role of Tissue Factor in Hemostasis, Thrombosis, and Vascular Development
Arterioscler Thromb Vasc Biol,
June 1, 2004;
24(6):
1015 - 1022.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Levi, T. T Keller, E. van Gorp, and H. ten Cate
Infection and inflammation and the coagulation system
Cardiovasc Res,
October 15, 2003;
60(1):
26 - 39.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. T Keller, A. T.A Mairuhu, M. D de Kruif, S. K Klein, V. E.A Gerdes, H. ten Cate, D. P.M Brandjes, M. Levi, and E. C.M van Gorp
Infections and endothelial cells
Cardiovasc Res,
October 15, 2003;
60(1):
40 - 48.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. van den Goor, A. van den Brink, R. Nieuwland, W. van Oeveren, P. M. Rutten, R. Tepaske, J. G. Tijssen, A. Sturk, B. A. de Mol, and L. Eijsman
Generation of platelet-derived microparticles in patients undergoing cardiac surgery is not affected by complement activation
J. Thorac. Cardiovasc. Surg.,
October 1, 2003;
126(4):
1101 - 1106.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Shet, O. Aras, K. Gupta, M. J. Hass, D. J. Rausch, N. Saba, L. Koopmeiners, N. S. Key, and R. P. Hebbel
Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes
Blood,
October 1, 2003;
102(7):
2678 - 2683.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. VanWijk, E. VanBavel, A. Sturk, and R. Nieuwland
Microparticles in cardiovascular diseases
Cardiovasc Res,
August 1, 2003;
59(2):
277 - 287.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. C. Aird
The Hematologic System as a Marker of Organ Dysfunction in Sepsis
Mayo Clin. Proc.,
July 1, 2003;
78(7):
869 - 881.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Falati, Q. Liu, P. Gross, G. Merrill-Skoloff, J. Chou, E. Vandendries, A. Celi, K. Croce, B. C. Furie, and B. Furie
Accumulation of Tissue Factor into Developing Thrombi In Vivo Is Dependent upon Microparticle P-Selectin Glycoprotein Ligand 1 and Platelet P-Selectin
J. Exp. Med.,
June 2, 2003;
197(11):
1585 - 1598.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. W. Kang, S. Y. Choi, M. K. Cho, C. H. Lee, and S. G. Kim
Thrombin Induces Nitric-oxide Synthase via Galpha 12/13-coupled Protein Kinase C-dependent I-kappa Balpha Phosphorylation and JNK-mediated I-kappa Balpha Degradation
J. Biol. Chem.,
May 2, 2003;
278(19):
17368 - 17378.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Cloez-Tayarani, A.-F. Petit-Bertron, H. D. Venters, and J.-M. Cavaillon
Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptors
Int. Immunol.,
February 1, 2003;
15(2):
233 - 240.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. E. Warkentin, W. C. Aird, and J. H. Rand
Platelet-Endothelial Interactions: Sepsis, HIT, and Antiphospholipid Syndrome
Hematology,
January 1, 2003;
2003(1):
497 - 519.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Sjobring, U. Ringdahl, and Z. M. Ruggeri
Induction of platelet thrombi by bacteria and antibodies
Blood,
December 15, 2002;
100(13):
4470 - 4477.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Diamant, R. Nieuwland, R. F. Pablo, A. Sturk, J. W.A. Smit, and J. K. Radder
Elevated Numbers of Tissue-Factor Exposing Microparticles Correlate With Components of the Metabolic Syndrome in Uncomplicated Type 2 Diabetes Mellitus
Circulation,
November 5, 2002;
106(19):
2442 - 2447.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Balasubramanian, E. Grabowski, A. Bini, and Y. Nemerson
Platelets, circulating tissue factor, and fibrin colocalize in ex vivo thrombi: real-time fluorescence images of thrombus formation and propagation under defined flow conditions
Blood,
September 26, 2002;
100(8):
2787 - 2792.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Sabatier, V. Roux, F. Anfosso, L. Camoin, J. Sampol, and F. Dignat-George
Interaction of endothelial microparticles with monocytic cells in vitro induces tissue factor-dependent procoagulant activity
Blood,
May 13, 2002;
99(11):
3962 - 3970.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Brandtzaeg, A. Bjerre, R. Ovstebo, B. Brusletto, G. B. Joo, and P. Kierulf
Invited review: Neisseria meningitidis lipopolysaccharides in human pathology
Innate Immunity,
December 1, 2001;
7(6):
401 - 420.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Janowska-Wieczorek, M. Majka, J. Kijowski, M. Baj-Krzyworzeka, R. Reca, A. R. Turner, J. Ratajczak, S. G. Emerson, M. A. Kowalska, and M. Z. Ratajczak
Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment
Blood,
November 15, 2001;
98(10):
3143 - 3149.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. R. Dalton, J. S. Krauss, D. G. Falls III, and G. K. Fuller
Granulocytic Fragments in Sepsis
Ann. Clin. Lab. Sci.,
October 1, 2001;
31(4):
365 - 368.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Andre, D. Hartwell, I. Hrachovinova, S. Saffaripour, and D. D. Wagner
Pro-coagulant state resulting from high levels of soluble P-selectin in blood
PNAS,
December 5, 2000;
97(25):
13835 - 13840.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
