|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 95 No. 5 (March 1), 2000:
pp. 1560-1564
Association between diabetic retinopathy and genetic variations
in  2 1 integrin, a platelet receptor for collagen
Yumiko Matsubara,
Mitsuru Murata,
Taro Maruyama,
Makoto Handa,
Norihiko Yamagata,
Gentaro Watanabe,
Takao Saruta, and
Yasuo Ikeda
From the Department of Medicine, School of Medicine, Keio
University, Tokyo; Saitama Social Insurance Hospital, Saitama, Blood
Center, Keio University, Tokyo; and the Hibiya Medical Center, Sakura
Bank, Tokyo, Japan.
Platelets might be involved in the pathogenesis of diabetic
microangiopathy. Wide interindividual variations in the density of a
platelet collagen receptor ( 2 1 integrin or glycoprotein Ia/IIa)
are reportedly associated with polymorphism(s) in the gene encoding the
subunit of the receptor, including a Bgl II polymorphism in intron
7. The aim of the present study was to determine the relationship
between the Bgl II polymorphism and the susceptibility to diabetic
microangiopathy. A case-control study comparing 227 patients with type
II diabetes mellitus (119 with versus 108 without diabetic retinopathy)
as well as 169 nondiabetic subjects demonstrated that genotypes with
Bgl II (+) allele had a significant increase in the risk for
retinopathy. The odds ratio for Bgl II (+/+) to Bgl II ( /)
was 3.41 (95% CI, 1.49-7.78, P = .0036) when analysis was
confined to those with a disease duration of diabetes of 10 years or
more. The present study suggests that the presence of a Bg II (+)
allele is a genetic risk factor for diabetic retinopathy.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
Y. Cheli and T. J. Kunicki
hnRNP L regulates differences in expression of mouse integrin {alpha}2beta1
Blood,
June 1, 2006;
107(11):
4391 - 4398.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Kunicki, A. B. Federici, D. R. Salomon, J. A. Koziol, S. R. Head, T. S. Mondala, J. D. Chismar, L. Baronciani, M. T. Canciani, and I. R. Peake
An association of candidate gene haplotypes and bleeding severity in von Willebrand disease (VWD) type 1 pedigrees
Blood,
October 15, 2004;
104(8):
2359 - 2367.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Fiorina, F. Folli, A. D'Angelo, G. Finzi, F. Pellegatta, V. Guzzi, C. Fedeli, P. D. Valle, L. Usellini, C. Placidi, et al.
Normalization of Multiple Hemostatic Abnormalities in Uremic Type 1 Diabetic Patients After Kidney-Pancreas Transplantation
Diabetes,
September 1, 2004;
53(9):
2291 - 2300.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gruner, M. Prostredna, V. Schulte, T. Krieg, B. Eckes, C. Brakebusch, and B. Nieswandt
Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo
Blood,
December 1, 2003;
102(12):
4021 - 4027.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. He, L. K. Pappan, D. G. Grenache, Z. Li, D. M. Tollefsen, S. A. Santoro, and M. M. Zutter
The contributions of the {alpha}2{beta}1 integrin to vascular thrombosis in vivo
Blood,
November 15, 2003;
102(10):
3652 - 3657.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Grenache, T. Coleman, C. F. Semenkovich, S. A. Santoro, and M. M. Zutter
{alpha}2{beta}1 Integrin and Development of Atherosclerosis in a Mouse Model: Assessment of Risk
Arterioscler. Thromb. Vasc. Biol.,
November 1, 2003;
23(11):
2104 - 2109.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Nieswandt and S. P. Watson
Platelet-collagen interaction: is GPVI the central receptor?
Blood,
July 15, 2003;
102(2):
449 - 461.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Pontiggia, R. Lassila, S. Pederiva, H.-R. Schmid, M. Burger, and J. H. Beer
Increased Platelet-Collagen Interaction Associated With Double Homozygosity for Receptor Polymorphisms of Platelet GPIa and GPIIIa
Arterioscler. Thromb. Vasc. Biol.,
December 1, 2002;
22(12):
2093 - 2098.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Chen, T. G. Diacovo, D. G. Grenache, S. A. Santoro, and M. M. Zutter
The {alpha}2 Integrin Subunit-Deficient Mouse : A Multifaceted Phenotype Including Defects of Branching Morphogenesis and Hemostasis
Am. J. Pathol.,
July 1, 2002;
161(1):
337 - 344.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Maeno, H. Koyama, H. Tahara, M. Komatsu, M. Emoto, T. Shoji, M. Inaba, T. Miki, Y. Okuno, and Y. Nishizawa
The 807T Allele in {alpha}2 Integrin Is Protective Against Atherosclerotic Arterial Wall Thickening and the Occurrence of Plaque in Patients With Type 2 Diabetes
Diabetes,
May 1, 2002;
51(5):
1523 - 1528.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Awata, K. Inoue, S. Kurihara, T. Ohkubo, M. Watanabe, K. Inukai, I. Inoue, and S. Katayama
A Common Polymorphism in the 5'-Untranslated Region of the VEGF Gene Is Associated With Diabetic Retinopathy in Type 2 Diabetes
Diabetes,
May 1, 2002;
51(5):
1635 - 1639.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Kunicki
The Influence of Platelet Collagen Receptor Polymorphisms in Hemostasis and Thrombotic Disease
Arterioscler. Thromb. Vasc. Biol.,
January 1, 2002;
22(1):
14 - 20.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Kunicki and Z. M. Ruggeri
Platelet Collagen Receptors and Risk Prediction in Stroke and Coronary Artery Disease
Circulation,
September 25, 2001;
104(13):
1451 - 1453.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Jacquelin, M. D. Tarantino, M. Kritzik, D. Rozenshteyn, J. A. Koziol, A. T. Nurden, and T. J. Kunicki
Allele-dependent transcriptional regulation of the human integrin {alpha}2 gene
Blood,
March 15, 2001;
97(6):
1721 - 1726.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Jacquelin, D. Rozenshteyn, S. Kanaji, J. A. Koziol, A. T. Nurden, and T. J. Kunicki
Characterization of Inherited Differences in Transcription of the Human Integrin alpha 2 Gene
J. Biol. Chem.,
June 22, 2001;
276(26):
23518 - 23524.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
