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Related Collections Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, Vol. 95 No. 5 (March 1), 2000: pp. 1560-1564 Association between diabetic retinopathy and genetic variations in 21 integrin, a platelet receptor for collagen Yumiko Matsubara, Mitsuru Murata, Taro Maruyama, Makoto Handa, Norihiko Yamagata, Gentaro Watanabe, Takao Saruta, and Yasuo Ikeda From the Department of Medicine, School of Medicine, Keio University, Tokyo; Saitama Social Insurance Hospital, Saitama, Blood Center, Keio University, Tokyo; and the Hibiya Medical Center, Sakura Bank, Tokyo, Japan. Platelets might be involved in the pathogenesis of diabetic microangiopathy. Wide interindividual variations in the density of a platelet collagen receptor (21 integrin or glycoprotein Ia/IIa) are reportedly associated with polymorphism(s) in the gene encoding the subunit of the receptor, including a Bgl II polymorphism in intron 7. The aim of the present study was to determine the relationship between the Bgl II polymorphism and the susceptibility to diabetic microangiopathy. A case-control study comparing 227 patients with type II diabetes mellitus (119 with versus 108 without diabetic retinopathy) as well as 169 nondiabetic subjects demonstrated that genotypes with Bgl II (+) allele had a significant increase in the risk for retinopathy. The odds ratio for Bgl II (+/+) to Bgl II (/) was 3.41 (95% CI, 1.49-7.78, P = .0036) when analysis was confined to those with a disease duration of diabetes of 10 years or more. The present study suggests that the presence of a Bg II (+) allele is a genetic risk factor for diabetic retinopathy. 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