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Blood, Vol. 95 No. 5 (March 1), 2000:
pp. 1671-1679
Vasculogenesis in the day 6.5 to 9.5 mouse embryo
Christopher J. Drake and
Paul A. Fleming
From the Medical University of South Carolina, Department of Cell
Biology and the Cardiovascular Developmental Biology Center,
Charleston, SC.
The process of vasculogenesis was characterized in the 6.5- to
9.5-day mouse embryo and in allantoic culture by analysis of spatial
and temporal expression patterns of the endothelial or hematopoietic
lineage-associated proteins, TAL1, Flk1, platelet/endothelial cell
adhision molecule (PECAM), CD34, VE-cadherin, and Tie2. The study
establishes that: (1) TAL1 and Flk1 are coexpressed in isolated mesodermal cells that give rise to endothelial cells and thus can be
defined as angioblasts; (2) hematopoietic cells of blood islands
express TAL1, but not Flk1; (3) vasculogenesis in the embryo proper is
initiated by mesoderm fated to give rise to the endocardium; (4) the
maturation/morphogenesis of blood vessels can be defined in terms of a
sequential pattern of expression in which TAL1 and Flk1 are expressed
first followed by PECAM, CD34, VE-cadherin, and later Tie2; and (5)
TAL1 expression is down-regulated in endothelial cells of mature vessels.
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