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Blood, Vol. 95 No. 5 (March 1), 2000:
pp. 1872-1874
BRIEF REPORT
Progenitor cell mobilization by granulocyte colony-stimulating
factor controlled by loci on chromosomes 2 and 11
Masakazu Hasegawa,
Tracey M. Baldwin,
Donald Metcalf, and
Simon J. Foote
From the Walter and Eliza Hall Institute of Medical Research, Royal
Melbourne Hospital, Victoria, Australia.
Granulocyte colony-stimulating factor (G-CSF) can effectively
mobilize hematopoietic stem and progenitor cells from bone marrow into
blood, thereby allowing peripheral blood stem cells (PBSCs) to be used
for transplantation. The efficiency of PBSC mobilization response to
G-CSF is a multigene trait. DBA/2 (high-responder) and C57BL/6
(low-responder) mice were used for a genetic analysis of G-CSF-induced
progenitor release. Significant linkages were found on chromosome 2 by
analyzing segregation distortion among the high responders of 500 backcross mice and on chromosome 11 by using the quantitative trait
locus analysis of 26 strains of BXD recombinant inbred mice.
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