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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Carballo, E. Articles by Blackshear, P. J. Search for Related Content PubMed PubMed Citation Articles by Carballo, E. Articles by Blackshear, P. J. Related Collections Plenary Papers Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, Vol. 95 No. 6 (March 15), 2000: pp. 1891-1899 PLENARY PAPER Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability Ester Carballo, Wi S. Lai, and Perry J. Blackshear From the Office of Clinical Research and Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC, and Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC. Deficiency of tristetraprolin (TTP), the prototype of the CCCH zinc finger proteins, results in a complex inflammatory syndrome in mice. Most aspects of the syndrome are secondary to excess circulating tumor necrosis factor (TNF)-, a consequence of increased stability of TNF- messenger RNA (mRNA) in TTP-deficient macrophages. TTP can bind directly to the AU-rich element in TNF- mRNA, increasing its lability. Here we show that TTP deficiency also results in increased cellular production of granulocyte-macrophage colony-stimulating factor (GM-CSF) and increased stability of its mRNA, apparently secondary to decreased deadenylation. Similar findings were observed in mice also lacking both types of TNF- receptors, excluding excess TNF- production as a cause of the increased GM-CSF mRNA levels and stability. TTP appears to be a physiological regulator of GM-CSF mRNA deadenylation and stability. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. M. Schichl, U. Resch, R. Hofer-Warbinek, and R. de Martin Tristetraprolin Impairs NF-{kappa}B/p65 Nuclear Translocation J. Biol. Chem., October 23, 2009; 284(43): 29571 - 29581. [Abstract] [Full Text] [PDF] J. Liang, T. Lei, Y. Song, N. Yanes, Y. Qi, and M. Fu RNA-destabilizing Factor Tristetraprolin Negatively Regulates NF-{kappa}B Signaling J. Biol. Chem., October 23, 2009; 284(43): 29383 - 29390. [Abstract] [Full Text] [PDF] D. J. Stumpo, H. E. Broxmeyer, T. Ward, S. Cooper, G. Hangoc, Y. J. Chung, W. C. Shelley, E. K. Richfield, M. K. Ray, M. C. Yoder, et al. 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