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Blood, Vol. 95 No. 6 (March 15), 2000:
pp. 1900-1910
REVIEW ARTICLE
Cell adhesion receptors in lymphoma dissemination
Paul Drillenburg and
Steven T. Pals
Department of Pathology, Academic Medical Center, University of
Amsterdam, Amsterdam, The Netherlands.
Regulated lymphocyte trafficking is essential for the control and
integration of systemic immune responses. This homing process disperses
the immunologic repertoire, guides lymphocyte subsets to the
specialized microenvironments that control their differentiation and
survival, and targets immune effector cells to sites of antigenic insult. This review discusses data indicating that the adhesion receptors regulating the trafficking of normal lymphocytes are also
expressed and functionally active in their malignant counterparts, the
non-Hodgkin lymphomas. These "homing receptors" appear to mediate
the highly tissue-specific dissemination of specific lymphoma subtypes,
such as lymphomas of the mucosa-associated lymphoid tissues and
lymphomas of the skin. Furthermore, as a result of their capability to
enhance lymphoma dissemination and to transduce signals into the cell,
promoting cell growth and survival, adhesion receptors may contribute
to lymphoma aggressiveness. Taken together, the data offer a framework
for understanding the dissemination routes of non-Hodgkin lymphomas and
suggest that adhesion receptors, specifically those of the CD44 family,
may present useful tools to predict prognosis in patients with lymphomas.
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