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Blood, Vol. 95 No. 7 (April 1), 2000:
pp. 2198-2203
PLENARY PAPER
Selective elimination of leukemic CD34+ progenitor
cells by cytotoxic T lymphocytes specific for WT1
Liquan Gao,
Ilaria Bellantuono,
Annika Elsässer,
Stephen B. Marley,
Myrtle Y. Gordon,
John M. Goldman, and
Hans J. Stauss
From the Departments of Immunology and Hematology, Imperial School
of Medicine, Hammersmith Hospital, London, UK.
Hematologic malignancies such as acute and chronic myeloid leukemia
are characterized by the malignant transformation of immature CD34+ progenitor cells. Transformation is associated with
elevated expression of the Wilm's tumor gene encoded transcription
factor (WT1). Here we demonstrate that WT1 can serve as a target for cytotoxic T lymphocytes (CTL) with exquisite specificity for
leukemic progenitor cells. HLA-A0201- restricted CTL specific
for WT1 kill leukemia cell lines and inhibit colony formation by
transformed CD34+ progenitor cells isolated from patients
with chronic myeloid leukemia (CML), whereas colony formation by normal
CD34+ progenitor cells is unaffected. Thus, the
tissue-specific transcription factor WT1 is an ideal target for
CTL-mediated purging of leukemic progenitor cells in vitro and for
antigen-specific therapy of leukemia and other WT1-expressing
malignancies in vivo.
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January 1, 2000;
2000(1):
69 - 89.
[Abstract]
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M. Brenner, C. Rossig, U. Sili, J. W. Young, and E. Goulmy
Transfusion Medicine: New Clinical Applications of Cellular Immunotherapy
Hematology,
January 1, 2000;
2000(1):
356 - 375.
[Abstract]
[Full Text]
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