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Blood, Vol. 95 No. 7 (April 1), 2000:
pp. 2440-2442
BRIEF REPORT
Human natural killer T cells acquire a memory-activated phenotype
before birth
Hans J. J. van der Vliet,
Nobusuke Nishi,
Tanja
D. de Gruijl,
B. Mary E. von Blomberg,
Alfons J. M. van den Eertwegh,
Herbert M. Pinedo,
Giuseppe Giaccone, and
Rik J. Scheper
From the Departments of Medical Oncology and Pathology, University
Hospital Vrije Universiteit, Amsterdam, The Netherlands.
Natural killer T (NKT) cells have recently been shown to play an
important role in the rejection of malignant tumors and in the
regulation of autoimmune diseases. Potent antitumor effects of the
marine sponge-derived NKT cell ligand KRN7000 were observed in mice.
Therefore, the elucidation of the natural ligand of NKT cells, which is
currently still unknown, might have important clinical consequences for
the treatment of cancer and autoimmune diseases. Analysis of cord blood
mononuclear cells from healthy term infants demonstrated that in sharp
contrast with the vast majority of cord blood lymphocytes, human NKT
cells have already acquired a memory-activated phenotype before birth.
This observation indicates that NKT cells encounter a natural ligand
during fetal life and that this ligand is unlikely to be of microbial origin.
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