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Blood, Vol. 95 No. 7 (April 1), 2000:
pp. 2449-2451
BRIEF REPORT
X-linked genetic factors regulate hematopoietic stem-cell
kinetics in females
Kaare Christensen,
Marianne Kristiansen,
Heidi Hagen-Larsen,
Axel Skytthe,
Lise Bathum,
Bernard Jeune,
Karen Andersen-Ranberg,
James W. Vaupel, and
Karen Helene Ørstavik
From the Danish Twin Registry, Epidemiology, Institute of Public
Health, and the Danish Center for Demographic Research, University of
Southern Denmark, Main Campus, Odense University, Odense, Denmark, and
the Department of Medical Genetics, Ullevål University Hospital,
Oslo, Norway.
X inactivation makes females mosaics for 2 cell populations, usually
with an approximate 1:1 distribution. Skewing of this distribution in
peripheral blood cells is more common among elderly women.1-3 The depletion of hematopoietic stem cells
followed by random differentiation may explain the acquired skewing
with age.4 However, an animal model suggests that selection
processes based on X-linked genetic factors are
involved.5 We studied peripheral blood cells from 71 monozygotic twin pairs aged 73 to 93 years and from 33 centenarians,
and we found that with age, 1 of the cell populations becomes
predominant for most women. We also observed a strong tendency for the
same cell line to become predominant in 2 co-twins. This suggests that
X-linked genetic factors influence human hematopoietic stem cell
kinetics. The fact that females have 2 cell lines with different
potentials could be one of the reasons women live longer than men.
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