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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kleindienst, P. Articles by Brocker, T. Search for Related Content PubMed PubMed Citation Articles by Kleindienst, P. Articles by Brocker, T. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, Vol. 95 No. 8 (April 15), 2000: pp. 2610-2616 Functional comparison of thymic B cells and dendritic cells in vivo Petra Kleindienst, Isabelle Chretien, Thomas Winkler, and Thomas Brocker From the University Freiburg, Institute for Biology III, Max-Planck-Institute for Immunobiology, Freiburg, Germany, and the Basel Institute for Immunology, Basel, Switzerland. In this report we present a transgenic mouse model in which we targeted gene expression specifically to B-lymphocytes. Using the human CD19 promoter, we expressed major histocompatibility complex class II I-E molecules specifically on B cells of all tissues, but not on other cell types. If only B cells expressed I-E in a class II-deficient background, positive selection of CD4+ T cells could not be observed. A comparison of the frequencies of I-E reactive V5+ and V11+ T cells shows that I-E expression on thymic B cells is sufficient to negatively select I-E reactive CD4+ T cells partially, but not CD8+ T cells. Thus partial negative but no positive selection events can be induced by B-lymphocytes in vivo. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Ohnmacht, A. Pullner, S. B.S. King, I. Drexler, S. Meier, T. Brocker, and D. Voehringer Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity J. Exp. Med., March 16, 2009; 206(3): 549 - 559. [Abstract] [Full Text] [PDF] M. Werner-Klein, C. Dresch, P. Marconi, and T. Brocker Transcriptional Targeting of B Cells for Induction of Peripheral CD8 T Cell Tolerance J. Immunol., June 15, 2007; 178(12): 7738 - 7746. [Abstract] [Full Text] [PDF] M. A. Cannarile, N. Decanis, J. P. M. van Meerwijk, and T. Brocker The Role of Dendritic Cells in Selection of Classical and Nonclassical CD8+ T Cells In Vivo J. Immunol., October 15, 2004; 173(8): 4799 - 4805. [Abstract] [Full Text] [PDF] C. Joao, B. M. Ogle, C. Gay-Rabinstein, J. L. Platt, and M. Cascalho B Cell-Dependent TCR Diversification J. Immunol., April 15, 2004; 172(8): 4709 - 4716. [Abstract] [Full Text] [PDF] P. Kleindienst and T. Brocker Endogenous Dendritic Cells Are Required for Amplification of T Cell Responses Induced by Dendritic Cell Vaccines In Vivo J. Immunol., March 15, 2003; 170(6): 2817 - 2823. [Abstract] [Full Text] [PDF] S. Golby, M. Hackett, L. Boursier, D. Dunn-Walters, S. Thiagamoorthy, and J. Spencer B cell development and proliferation of mature B cells in human fetal intestine J. Leukoc. Biol., August 1, 2002; 72(2): 279 - 284. [Abstract] [Full Text] [PDF] E. Jimenez, A. Vicente, R. Sacedon, J. J. Munoz, G. Weinmaster, A. G. Zapata, and A. Varas Distinct Mechanisms Contribute to Generate and Change the CD4:CD8 Cell Ratio During Thymus Development: A Role for the Notch Ligand, Jagged1 J. Immunol., May 15, 2001; 166(10): 5898 - 5908. [Abstract] [Full Text] [PDF] C. Kurts, M. Cannarile, I. Klebba, and T. Brocker Cutting Edge: Dendritic Cells Are Sufficient to Cross-Present Self-Antigens to CD8 T Cells In Vivo J. Immunol., February 1, 2001; 166(3): 1439 - 1442. [Abstract] [Full Text] [PDF]

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