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Blood, Vol. 96 No. 1 (July 1), 2000:
pp. 170-175
Transfer of tissue factor from leukocytes to platelets is
mediated by CD15 and tissue factor
Ursula Rauch,
Diana Bonderman,
Bernd Bohrmann,
Juan J. Badimon,
Jacques Himber,
Markus A. Riederer, and
Yale Nemerson
From the Division of Thrombosis Research, Department of Medicine,
and The Zena and Michael A. Wiener Cardiovascular Institute, Mount
Sinai School of Medicine, New York, NY 10029; and F. Hoffmann La Roche
Ltd, Pharma Division, Preclinical Research, Basel, Switzerland.
We describe thrombogenic tissue factor (TF) on leukocyte-derived
microparticles and their incorporation into spontaneous human thrombi.
Polymorphonuclear leukocytes and monocytes transfer TF+
particles to platelets, thereby making them capable of triggering and
propagating thrombosis. This phenomenon calls into question the
original dogma that vessel wall injury and exposure of TF within the
vasculature to blood is sufficient for the occurrence of arterial
thrombosis. The transfer of TF+ leukocyte-derived
particles is dependent on the interaction of CD15 and TF with
platelets. Both the inhibition of TF transfer to platelets by
antagonizing the interaction CD15 with P-selectin and the direct
interaction of TF itself suggest a novel therapeutic approach to
prevent thrombosis.
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