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Blood, Vol. 96 No. 1 (July 1), 2000:
pp. 362-364
BRIEF REPORT
ESOP-1, a secreted protein expressed in the hematopoietic,
nervous, and reproductive systems of embryonic and adult mice
Keizo Kato,
Aline M. Morrison,
Toru Nakano,
Kei Tashiro, and
Tasuku Honjo
From the Department of Medical Chemistry, Faculty of Medicine, Kyoto
University, Yoshida, Sakyo-ku, and the Center for Molecular Biology and
Genetics, Kyoto University, Shogo-in, Sakyo-ku, Kyoto, Japan.
To isolate soluble factors expressed in early phases of
hematopoietic differentiation, we applied the signal sequence trap method to the in vitro murine hematopoietic differentiation system, in
which ES cells are cocultured with OP-9 stroma cells. This strategy
allowed us to isolate cDNA for a secreted protein, ESOP-1, of 160 amino
acids, the sequence of which shows 64% identity with human
ESOP-1/MD-2. ESOP-1 mRNA was highly expressed in the mouse embryos at
7.5 days after coitus. Expression of the ESOP-1 mRNA and protein was
shown in the embryonic and adult hematopoietic system. In addition, the
ESOP-1 protein was found in the yolk sac-blood islands, the developing
nervous system, and the adult reproductive system. These results
suggest that ESOP-1 may play some roles in the development or
maintenance of hematopoietic, nervous, and reproductive systems.
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