|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 December 2000, Vol. 96, No. 12, pp. 3982-3984
BRIEF REPORT
Linkage analysis for major histocompatibility complex-related
genetic susceptibility in familial chronic lymphocytic
leukemia
Stephen Bevan,
Daniel Catovsky,
Estella Matutes,
Petar Antunovic,
Martin J. Auger,
Isaac Ben-Bassat,
Andrew Bell,
Alain Berrebi,
Elizabeth J. Gaminara,
Maria E. Júnior,
Francesca R. Mauro,
Klas Quabeck,
Saad M. B. Rassam,
Cecil Reid,
Isabel Ribeiro,
Pinhas Stark,
Jacques J. M. van Dongen,
Jennifer Wimperis,
Susan Wright,
Andrea Marossy,
Martin R. Yuille, and
Richard S. Houlston
From the Institute of Cancer Research, Sutton,
United Kingdom; Regionsykenhuset I Tromsø, Tromsø, Norway; The
Kings Mill Centre, Sutton-in-Ashfield, United Kingdom; Sheba Medical
Centre, Sackler School of Medicine, Tel-Hashomer, Israel; Poole General
Hospital, Poole, United Kingdom; Kaplan Medical Center, Rehovot,
Israel; St Albans City Hospital, St Albans, United Kingdom; Hospital de
Santa Cruz, Carnaxide, Portugal; La Sapienza University, Rome, Italy;
Group Practice for Haematology and Oncology, Duisburg, Germany; Queen
Mary's Hospital, Sidcup, United Kingdom; Northwick Park Hospital,
Harrow, United Kingdom; Hospital de Egas Moniz, Lisboa, Portugal; Rabin
Medical Centre, Petah-Tiqva, Israel; Erasmus University Rotterdam,
Rotterdam, The Netherlands; Norfolk and Norwich Hospital, Norwich,
United Kingdom; and Mater Misericordiae Hospitals, South Brisbane,
Australia.
Chronic lymphocytic leukemia (CLL) shows evidence of familial
aggregation, but the genetic basis is poorly understood. The existence
of a linkage between HLA and Hodgkin lymphoma, another B-cell disorder,
coupled with the fact that CLL is frequently associated with autoimmune
disease, led to the question of whether the major histocompatibility
complex (MHC) region is involved in familial cases of CLL. To examine
this proposition, 5 microsatellite markers on chromosome 6p21.3 were
typed in 28 families with CLL, 4 families with CLL in association with
other lymphoproliferative disorders, and 1 family with splenic lymphoma
with villous lymphocytes. There was no evidence of linkage in these
families to chromosome 6p21.3. The best estimates of the proportions of
sibling pairs with CLL that share 0, 1, or 2 MHC haplotypes were not
significantly different from the null expectation. This implies that
genes within the MHC region are unlikely to be the major determinants
of familial CLL.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
L. R. Goldin, R. M. Pfeiffer, X. Li, and K. Hemminki
Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database
Blood,
September 15, 2004;
104(6):
1850 - 1854.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Inoue, A. Marx, A. Zettl, P. Strobel, H.-K. Muller-Hermelink, and P. Starostik
Chromosome 6 Suffers Frequent and Multiple Aberrations in Thymoma
Am. J. Pathol.,
October 1, 2002;
161(4):
1507 - 1513.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
