|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 December 2000, Vol. 96, No. 13, pp. 4020-4027
REVIEW ARTICLE
Iron homeostasis: new tales from the crypt
Cindy N. Roy and
Caroline
A. Enns
From the Department of Cell and Developmental Biology,
Oregon Health Sciences University, Portland, OR.
The enterocyte is a highly specialized cell of the duodenal
epithelium that coordinates iron uptake and transport into the body.
Until recently, the molecular mechanisms underlying iron absorption and
iron homeostasis have remained a mystery. This review focuses on the
proteins and regulatory mechanisms known to be present in the
enterocyte precursor cell and in the mature enterocyte. The recent
cloning of a basolateral iron transporter and investigations into its
regulation provide new insights into possible mechanisms for iron
transport and homeostasis. The roles of proteins such as iron
regulatory proteins, the hereditary hemochromatosis protein
(HFE)-transferrin receptor complex, and hephaestin in regulating this
transporter and in regulating iron transport across the intestinal
epithelium are discussed. A speculative, but testable, model for the
maintenance of iron homeostasis, which incorporates the changes in the
iron-related proteins associated with the life cycle of the enterocyte
as it journeys from the crypt to the tip of the villous is proposed.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
N. C. Andrews
Forging a field: the golden age of iron biology
Blood,
July 15, 2008;
112(2):
219 - 230.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. D. Ma and M. M. Udden
Iron metabolism, iron overload, and the porphyrias
ASH Self-Assessment Program,
January 1, 2007;
2007(1):
61 - 77.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Moriya and M. C. Linder
Vesicular transport and apotransferrin in intestinal iron absorption, as shown in the Caco-2 cell model
Am J Physiol Gastrointest Liver Physiol,
February 1, 2006;
290(2):
G301 - G309.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Galy, D. Ferring, B. Minana, O. Bell, H. G. Janser, M. Muckenthaler, K. Schumann, and M. W. Hentze
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)
Blood,
October 1, 2005;
106(7):
2580 - 2589.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Canavese, D. Bergamo, G. Ciccone, M. Burdese, E. Maddalena, S. Barbieri, A. Thea, and F. Fop
Low-dose continuous iron therapy leads to a positive iron balance and decreased serum transferrin levels in chronic haemodialysis patients
Nephrol. Dial. Transplant.,
June 1, 2004;
19(6):
1564 - 1570.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Lind, O. Hernell, B. Lonnerdal, H. Stenlund, M. Domellof, and L.-A. Persson
Dietary Iron Intake Is Positively Associated with Hemoglobin Concentration During Infancy but Not During the Second Year of Life
J. Nutr.,
May 1, 2004;
134(5):
1064 - 1070.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Mok, J. Jelinek, S. Pai, B. M. Cattanach, J. T. Prchal, H. Youssoufian, and A. Schumacher
Disruption of ferroportin 1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice
Development,
April 15, 2004;
131(8):
1859 - 1868.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Jacolot, G. Le Gac, V. Scotet, I. Quere, C. Mura, and C. Ferec
HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype
Blood,
April 1, 2004;
103(7):
2835 - 2840.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W.-I. Leong, C. L Bowlus, J. Tallkvist, and B. Lonnerdal
Iron supplementation during infancy--effects on expression of iron transporters, iron absorption, and iron utilization in rat pups
Am. J. Clinical Nutrition,
December 1, 2003;
78(6):
1203 - 1211.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ganz
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
Blood,
August 1, 2003;
102(3):
783 - 788.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. L. TUMA and A. L. HUBBARD
Transcytosis: Crossing Cellular Barriers
Physiol Rev,
July 1, 2003;
83(3):
871 - 932.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Pizarro, M. Olivares, E. Hertrampf, D. I. Mazariegos, and M. Arredondo
Heme-Iron Absorption Is Saturable by Heme-Iron Dose in Women
J. Nutr.,
July 1, 2003;
133(7):
2214 - 2217.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. G. Gehrke, H. Kulaksiz, T. Herrmann, H.-D. Riedel, K. Bents, C. Veltkamp, and W. Stremmel
Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron
Blood,
July 1, 2003;
102(1):
371 - 376.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. R. Zerounian, C. Redekosky, R. Malpe, and M. C. Linder
Regulation of copper absorption by copper availability in the Caco-2 cell intestinal model
Am J Physiol Gastrointest Liver Physiol,
May 1, 2003;
284(5):
G739 - G747.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. G. Gehrke, H.-D. Riedel, T. Herrmann, B. Hadaschik, K. Bents, C. Veltkamp, and W. Stremmel
UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis
Blood,
April 15, 2003;
101(8):
3288 - 3293.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Simpson, E. S. Debnam, A. H. Laftah, N. Solanky, N. Beaumont, S. Bahram, K. Schumann, and S. K. S. Srai
Duodenal nonheme iron content correlates with iron stores in mice, but the relationship is altered by Hfe gene knock-out
Blood,
April 15, 2003;
101(8):
3316 - 3318.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R J Simpson, E Debnam, N Beaumont, S Bahram, K Schumann, and S K S Srai
Duodenal mucosal reductase in wild-type and Hfe knockout mice on iron adequate, iron deficient, and iron rich feeding
Gut,
April 1, 2003;
52(4):
510 - 513.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. de Silva, S. Atukorala, I. Weerasinghe, and N. Ahluwalia
Iron supplementation improves iron status and reduces morbidity in children with or without upper respiratory tract infections: a randomized controlled study in Colombo, Sri Lanka
Am. J. Clinical Nutrition,
January 1, 2003;
77(1):
234 - 241.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Deaglio, A. Capobianco, A. Cali, F. Bellora, F. Alberti, L. Righi, A. Sapino, C. Camaschella, and F. Malavasi
Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum
Blood,
November 15, 2002;
100(10):
3782 - 3789.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F Dupic, S Fruchon, M Bensaid, O Loreal, P Brissot, N Borot, M P Roth, and H Coppin
Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice
Gut,
November 1, 2002;
51(5):
648 - 653.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Trinder, J. K. Olynyk, W. S. Sly, and E. H. Morgan
Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse
PNAS,
April 8, 2002;
(2002)
82112299.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Nicolas, M. Bennoun, A. Porteu, S. Mativet, C. Beaumont, B. Grandchamp, M. Sirito, M. Sawadogo, A. Kahn, and S. Vaulont
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
PNAS,
April 2, 2002;
99(7):
4596 - 4601.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Han and M. Wessling-Resnick
Copper repletion enhances apical iron uptake and transepithelial iron transport by Caco-2 cells
Am J Physiol Gastrointest Liver Physiol,
March 1, 2002;
282(3):
G527 - G533.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Green, W. E. Antholine, S. J. Wong, D. R. Richardson, and C. R. Chitambar
Inhibition of Malignant Cell Growth by 311, a Novel Iron Chelator of the Pyridoxal Isonicotinoyl Hydrazone Class: Effect on the R2 subunit of Ribonucleotide Reductase
Clin. Cancer Res.,
November 1, 2001;
7(11):
3574 - 3579.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Kozyraki, J. Fyfe, P. J. Verroust, C. Jacobsen, A. Dautry-Varsat, J. Gburek, T. E. Willnow, E. I. Christensen, and S. K. Moestrup
Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia
PNAS,
October 12, 2001;
(2001)
211291398.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. E. Fleming and W. S. Sly
Hepcidin: A putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease
PNAS,
July 17, 2001;
98(15):
8160 - 8162.
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Nicolas, M. Bennoun, I. Devaux, C. Beaumont, B. Grandchamp, A. Kahn, and S. Vaulont
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
PNAS,
July 5, 2001;
(2001)
151179498.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Knutson, J. E. Levy, N. C. Andrews, and M. Wessling-Resnick
Expression of Stimulator of Fe Transport Is Not Enhanced in Hfe Knockout Mice
J. Nutr.,
May 1, 2001;
131(5):
1459 - 1464.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
D. Trinder, J. K. Olynyk, W. S. Sly, and E. H. Morgan
Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse
PNAS,
April 16, 2002;
99(8):
5622 - 5626.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Nicolas, M. Bennoun, I. Devaux, C. Beaumont, B. Grandchamp, A. Kahn, and S. Vaulont
From the Cover: Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
PNAS,
July 17, 2001;
98(15):
8780 - 8785.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Kozyraki, J. Fyfe, P. J. Verroust, C. Jacobsen, A. Dautry-Varsat, J. Gburek, T. E. Willnow, E. I. Christensen, and S. K. Moestrup
Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia
PNAS,
October 23, 2001;
98(22):
12491 - 12496.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
